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Therapeutic time window for methylprednisolone in spinal cord injured rat

Authors
 Do Heum Yoon  ;  Young Soo Kim  ;  Wise Young 
Citation
 YONSEI MEDICAL JOURNAL, Vol.40(4) : 313-320, 1999 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
1999
MeSH
Animals ; Drug Administration Schedule ; Male ; Methylprednisolone Hemisuccinate/administration & dosage* ; Methylprednisolone Hemisuccinate/therapeutic use ; Neuroprotective Agents/administration & dosage* ; Neuroprotective Agents/therapeutic use ; Rats ; Rats, Long-Evans ; Spinal Cord/pathology ; Spinal Cord Injuries/drug therapy* ; Spinal Cord Injuries/pathology
Keywords
methylprednisolone ; spinal cord injury ; therapeutic time window
Abstract
Recent clinical trials have reported that methylprednisolone sodium succinate administered within 8 hours improves neurological recovery in human spinal cord injury (SCI). Methylprednisolone, however, was ineffective and possibly even deleterious when given more than 8 hours after injury. This finding suggests that a therapeutic time window exists in spinal cord injury. In order to determine the doses, durations and timing of methylprednisolone treatment for optimal neuroprotection, a single or two bolus dose of methylprednisolone (30 mg/kg) was administered at 10, 30, 120, 150 and 240 min. after three graded spinal cord injury. The primary outcome measure was 24-hour spinal cord lesion volumes estimated from spinal cord Na+ and K+ shifts. A single 30 mg/kg dose of methylprednisolone at 10 min. after injury significantly reduced 24-hour lesion volumes in injured rat spinal cords. However, any other methylprednisolone treatment starting 30 min. or more after injury had no effect on 24-hour lesion volumes compared to the vehicle control group. Moreover, delayed treatment increased lesion volumes in some cases. These results suggest that the NYU SCI model has a very short therapeutic window.
Files in This Item:
T199902178.pdf Download
DOI
10.3349/ymj.1999.40.4.313
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Do Heum(윤도흠) ORCID logo https://orcid.org/0000-0003-1452-5724
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/172743
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