Cited 29 times in
Therapeutic time window for methylprednisolone in spinal cord injured rat
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤도흠 | - |
dc.date.accessioned | 2019-11-26T01:06:33Z | - |
dc.date.available | 2019-11-26T01:06:33Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/172743 | - |
dc.description.abstract | Recent clinical trials have reported that methylprednisolone sodium succinate administered within 8 hours improves neurological recovery in human spinal cord injury (SCI). Methylprednisolone, however, was ineffective and possibly even deleterious when given more than 8 hours after injury. This finding suggests that a therapeutic time window exists in spinal cord injury. In order to determine the doses, durations and timing of methylprednisolone treatment for optimal neuroprotection, a single or two bolus dose of methylprednisolone (30 mg/kg) was administered at 10, 30, 120, 150 and 240 min. after three graded spinal cord injury. The primary outcome measure was 24-hour spinal cord lesion volumes estimated from spinal cord Na+ and K+ shifts. A single 30 mg/kg dose of methylprednisolone at 10 min. after injury significantly reduced 24-hour lesion volumes in injured rat spinal cords. However, any other methylprednisolone treatment starting 30 min. or more after injury had no effect on 24-hour lesion volumes compared to the vehicle control group. Moreover, delayed treatment increased lesion volumes in some cases. These results suggest that the NYU SCI model has a very short therapeutic window. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Drug Administration Schedule | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Methylprednisolone Hemisuccinate/administration & dosage* | - |
dc.subject.MESH | Methylprednisolone Hemisuccinate/therapeutic use | - |
dc.subject.MESH | Neuroprotective Agents/administration & dosage* | - |
dc.subject.MESH | Neuroprotective Agents/therapeutic use | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Long-Evans | - |
dc.subject.MESH | Spinal Cord/pathology | - |
dc.subject.MESH | Spinal Cord Injuries/drug therapy* | - |
dc.subject.MESH | Spinal Cord Injuries/pathology | - |
dc.title | Therapeutic time window for methylprednisolone in spinal cord injured rat | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학교실) | - |
dc.contributor.googleauthor | Do Heum Yoon | - |
dc.contributor.googleauthor | Young Soo Kim | - |
dc.contributor.googleauthor | Wise Young | - |
dc.identifier.doi | 10.3349/ymj.1999.40.4.313 | - |
dc.contributor.localId | A02546 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 10487132 | - |
dc.subject.keyword | methylprednisolone | - |
dc.subject.keyword | spinal cord injury | - |
dc.subject.keyword | therapeutic time window | - |
dc.contributor.alternativeName | Yoon, Do Heum | - |
dc.contributor.affiliatedAuthor | 윤도흠 | - |
dc.citation.volume | 40 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 313 | - |
dc.citation.endPage | 320 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.40(4) : 313-320, 1999 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.