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알코올 의존 치료를 위한 아캄프로세이트의 임상적 사용

Other Titles
 Treatment of Alcohol Dependence with Acamprosate 
 이필구  ;  이병욱  ;  최문종  ;  이충헌  ;  남궁기 
 Journal of Korean Academy fo Addiction Psychiatry (중독정신의학), Vol.4(1) : 3-10, 2000 
Journal Title
 Journal of Korean Academy fo Addiction Psychiatry (중독정신의학) 
Issue Date
Acamprosate (calcium bis acetylhomotaurinate) is a new medication that appears to be clinically useful in the treatment of alcohol dependence. Although it has proved effective in reducing relapse into drinking in clinical trials its exact neurochemical mechanism of action is not clear yet. Evidence is presented that the drug does not act in any of the conventional ways to reduce alcohol intake or psychotropical medication and it is proposed that it may be a novel kind of agent that suppresses craving. On the basis of its known pharmacological effects in pre-clinical studies it is suggested that acamprosate may reduce craving that is associated with conditioned negative withdrawal. Current trends of the prescriptions through European countries show its therapeutic effectiveness and availability. In addition to the potential therapeutic value of acamprosate, the drug may be useful because work directed toward understanding its mechanism of action may shed light on some of the fundamental processes that constitute alcohol abuse and relapse in weaned alcohol dependent patients.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Namkoong, Kee(남궁기) ORCID logo https://orcid.org/0000-0003-1400-8057
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