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파라콰트 중독 흰쥐에서 항산화제 U-74389G의 치료 효과

Other Titles
 Effect of Antioxidant, U-74389G, on Paraquat-Intoxicated Rats 
 오진호  ;  정성필  ;  임 훈  ;  노성훈  ;  김혜영  ;  김승호  ;  이한식  ;  민진식 
 Journal of the Korean Society of Emergency Medicine (대한응급의학회지), Vol.11(4) : 437-442, 2000 
Journal Title
Journal of the Korean Society of Emergency Medicine(대한응급의학회지)
Issue Date
Paraquat ; Lipid peroxidation ; Antioxidant ; Aminosteroid
Background: This study was conducted to verify the hypothesis that the suppression of lipid peroxidation with the antioxidant, U-74389G, could improve the survivability of paraquat intoxicated rats.
Methods: First, we obtained the 24-h mortality by using several paraquat dosages and calculated the 24-h LD50 in 24 male Wistar rats(250~350 g). To examine the effect of U-74389G, we divided the rats in 4 groups: a control group and U-74389G only group, a paraquat only group, and a paraquat plus U-74389G group(n=10 each). Paraquat, 35 mg/kg, was injected intraperitoneally at 0 h. U-74389G, 10mg/kg, was administered intraperitoneally at 0, 12 h or at 1, 12 h in the respective groups. The rats were observed for 24 hours. At 24 h, plasma and lung, liver, and idney tissues were obtained after sacrificing the surviving rats to determine the degree of lipid peroxidation by using a thiobarbituric acid reactive
substances(TBARS) quantitative analysis.
Results: The 24-h LD50 of paraquat was calculated as 40 mg/kg in our rats. The 24-h mortality was as follows: control group and U-74389G group 0%, paraquat group 30%, and paraquat plus U-74389G group 10%. The TBARS analysis showed no differences between the U-74389G and the control groups. The paraquat group showed significantly increased TBARS levels in the serum and in the kidney and lung tissue compared to the control group(p<0.05). With U-74389G, the increased TBARS levels were significantly decreased in the plasma, kidney, and lung tissues compared to the paraquat group(p<0.05). However, in the liver tissue, there were no significant differences among the groups.
Conclusion: A 21-aminosteroid antioxidant, U-74389G, improved the survivablity of paraquatintoxicated rats through the suppression of lipid peroxidation. Our result suggests the possibility of clinical application of this drug as an antidote for paraquat poisoning.
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1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Ho(김승호)
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