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간암 고위험군의 조기진단을 위한 선별검사(Screening) 방안 수립 및 효과 평가 연구

Other Titles
 Establishment of a Screenig Test System for Early Diagnosis of Hepatocellular Carcinoma in High-Risk Patients and the Evaluation of Its Effectiveness 
Authors
 한광협  ;  안상훈  ;  김동기  ;  송기준  ;  정정일  ;  이관식  ;  정재복  ;  전재윤  ;  문영명  ;  서일  ;  남정모 
Citation
 Journal of the Korean Cancer Association (대한암학회지), Vol.32(6) : 1084-1092, 2000 
Journal Title
Journal of the Korean Cancer Association(대한암학회지)
ISSN
 0496-6872 
Issue Date
2000
Keywords
Ultrasonograsphy ; Screening ; Hepatocellular carcinoma ; Risk factors
Abstract
PURPOSE:
To evaluate the effectiveness of clinic-based screening program for early detection of hepatocellular carcinoma (HCC) and to assess the risk factors of HCC in Korea.
MATERIALS AND METHODS:
The data of 14,259 patients who had ultrasonography (US) due to chronic liver diseases were collected into a data base program from 1990 to 1998.
RESULTS:
A total of 4,339 patients were enrolled who had repeated US. 237 patients were diagnosed as HCC during follow-up (mean 33 months). The tumor size detected by screening within a 6-months interval was significantly smaller than that of a longer interval (2.7 cm vs 3.9 cm, P<0.01). The smaller the tumor was at detection, the longer the survival time was. Only 29.9% of HCC patients had an elevated serum alpha-fetoprotein (alphaFP) level above 400 ng/ml. Multivariate analysis showed liver cirrhosis, chronic hepatitis B or C and old age over 40 years to be significantly associated with an increased risk of HCC.
CONCLUSION:
The US screening within a 6-months interval is beneficial to high-risk patients over 40 years old through the early detection of HCC and prolonged survival. According to the risk factors, the necessity for screening test and proper interval should be reconsidered.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
Yonsei Authors
Nam, Chung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Suh, Il(서일) ORCID logo https://orcid.org/0000-0002-9689-7849
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Lee, Kwan Sik(이관식) ORCID logo https://orcid.org/0000-0002-3672-1198
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/172249
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