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Valproate에 의해 유발된 가역적 파킨슨증 1예

Other Titles
 A case of valproate-induced reversible parkinsonism 
 김선곤  ;  오승헌  ;  김원주 
 Journal of the Korean Neurological Association (대한신경과학회지), Vol.18(5) : 654-656, 2000 
Journal Title
Journal of the Korean Neurological Association(대한신경과학회지)
Issue Date
Valproic acid ; Parkinson disease/Secondary
Valproate is one of the most popular conventional anti-epileptic drugs. It has many side effects and in rare cases, it may result in the development of parkinsonian syndromes. The parkinsonism with valproate shows insidious onset and reversible symptoms after drug withdrawal. We observed a 69-year-old woman with resting tremor, bradykinesia, cog-wheel rigidity after 2 months of valproate use. She had been suffering from epilepsy for 30 years. Her seizures were well controlled with valproate, but parkinsonian symptoms slowly progressed with doses of 1200 mg/day of valproate. After 4 months, we discontinued the doses of valproate which led to subjective and objective improvement of the parkinsonian features. The mechanism of this side effect is not well established, but GABAergic neurotransmission or mitochondrial respiratory chain may possibly be related.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Joo(김원주) ORCID logo https://orcid.org/0000-0002-5850-010X
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