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자간전증 산모의 제대동맥에서 혈관내피세포의 기능의 변화

Other Titles
 Attenuation of endothelial relaxation in umbilical arteries from preeclampsia patients 
 최형민  ;  박용원  ;  김세광  ;  김재욱  ;  안덕선  ;  강복순 
 Korean Journal of Obstetrics and Gynecology (대한산부인과학회잡지), Vol.43(6) : 1043-1095, 2000 
Journal Title
Korean Journal of Obstetrics and Gynecology(대한산부인과학회잡지)
Issue Date
Preeclampsia ; Umbilical artery ; Vasoactive substance ; Endothelial cell dependent relaxation(EDR) ; Endothelial cell independent relaxation
Objectives &Methods : To directly examine the function of the endothelial cell(EC) and smooth muscle cell in umbilical arteries acquired from preeclampsia patients between June 1998 to November 1999, using a conventional tension measurement and bioassay experiment.
Results : Relaxation responses to EC-dependent relaxing agents including bradykinin and A23187 in human umbilical artery rings were significantly decreased in preeclampsia(p<0.01). Relaxation responses to EC-independent agents(SNP and SNAP) were also inhibited in umbilical artery rings acquired from preeclampsia patients(p<0.01). To test the change of endothelial cell function in preeclampsia without involvement of smooth muscle dysfunction, we used human umbilical artery and rabbit femoral artery as a donor and detector, respectively, in bioassay experiment. Relaxation responses to EC-dependent agents(A23187 and bradykinin) showed similar results to conventional tension measurement (p<0.01). Relaxation responses to 8-bromo-cGMP in human umbilical artery rings were also significantly decreased in preeclampsia(p<0.01).
Conclusion : It can be concluded that increased vascular resistance in preeclampsia is not only due to the disturbance of endothelial function, but also to smooth muscle dysfunction.
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1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Park, Yong Won(박용원)
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