Cited 0 times in
자간전증 산모의 제대동맥에서 혈관내피세포의 기능의 변화
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박용원 | - |
dc.date.accessioned | 2019-11-11T05:46:22Z | - |
dc.date.available | 2019-11-11T05:46:22Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 0494-4755 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/172153 | - |
dc.description.abstract | Objectives &Methods : To directly examine the function of the endothelial cell(EC) and smooth muscle cell in umbilical arteries acquired from preeclampsia patients between June 1998 to November 1999, using a conventional tension measurement and bioassay experiment. Results : Relaxation responses to EC-dependent relaxing agents including bradykinin and A23187 in human umbilical artery rings were significantly decreased in preeclampsia(p<0.01). Relaxation responses to EC-independent agents(SNP and SNAP) were also inhibited in umbilical artery rings acquired from preeclampsia patients(p<0.01). To test the change of endothelial cell function in preeclampsia without involvement of smooth muscle dysfunction, we used human umbilical artery and rabbit femoral artery as a donor and detector, respectively, in bioassay experiment. Relaxation responses to EC-dependent agents(A23187 and bradykinin) showed similar results to conventional tension measurement (p<0.01). Relaxation responses to 8-bromo-cGMP in human umbilical artery rings were also significantly decreased in preeclampsia(p<0.01). Conclusion : It can be concluded that increased vascular resistance in preeclampsia is not only due to the disturbance of endothelial function, but also to smooth muscle dysfunction. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | Korean | - |
dc.publisher | 대한산부인과학회 | - |
dc.relation.isPartOf | Korean Journal of Obstetrics and Gynecology (대한산부인과학회잡지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 자간전증 산모의 제대동맥에서 혈관내피세포의 기능의 변화 | - |
dc.title.alternative | Attenuation of endothelial relaxation in umbilical arteries from preeclampsia patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics and Gynecology (산부인과학교실) | - |
dc.contributor.googleauthor | 최형민 | - |
dc.contributor.googleauthor | 박용원 | - |
dc.contributor.googleauthor | 김세광 | - |
dc.contributor.googleauthor | 김재욱 | - |
dc.contributor.googleauthor | 안덕선 | - |
dc.contributor.googleauthor | 강복순 | - |
dc.contributor.localId | A01581 | - |
dc.relation.journalcode | J02075 | - |
dc.identifier.url | http://kiss.kstudy.com/thesis/thesis-view.asp?key=1857390 | - |
dc.subject.keyword | Preeclampsia | - |
dc.subject.keyword | Umbilical artery | - |
dc.subject.keyword | Vasoactive substance | - |
dc.subject.keyword | Endothelial cell dependent relaxation(EDR) | - |
dc.subject.keyword | Endothelial cell independent relaxation | - |
dc.contributor.alternativeName | Park, Yong Won | - |
dc.contributor.affiliatedAuthor | 박용원 | - |
dc.citation.volume | 43 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1043 | - |
dc.citation.endPage | 1095 | - |
dc.identifier.bibliographicCitation | Korean Journal of Obstetrics and Gynecology (대한산부인과학회잡지), Vol.43(6) : 1043-1095, 2000 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.