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TNM Stage IVa의 진행성 간암에서 간동맥내 항암제 주입약제에 따른 치료성적과 예후인자

Other Titles
 Treatment Outcome and Prognostic Factors in Patients with Advanced Hepatocellular Carcinoma (TNM Stage IVa) according to Anticancer drugs of Transhepatic Arterial Chemoinfusion 
 안상훈  ;  한광협  ;  윤영훈  ;  김명환  ;  송건훈  ;  이관식  ;  전재윤  ;  문영명  ;  이도연  ;  이종태 
 Korean Journal of Hepatology (대한간학회지), Vol.6(4) : 456-467, 2000 
Journal Title
Korean Journal of Hepatology(대한간학회지)
Issue Date
Neoplasm/ Liver/Hepatocellular carcinoma ; Treatment out come ; Prognostic factors ; Intraarterial infusion ; Neoplasm staging
BACKGROUND/AIMS: The study proposed to evaluate the efficacy of anticancer drugs of intraarterial chemoinfusion and investigate prognostic factors influencing survival. METHODS: A total of 127 patients diagnosed as having advanced hepatocellular carcinoma(HCC) of same stage (TNM stage IVa) from 1996 to 1998 were examined. Two intraarterial infusion chemotherapeutic regimens were employed: Adriamycin(Group I) and Cisplatin(Group II). RESULTS: Overall survival was significantly diffrent(10.0 vs 5.7months) and favored Group I. By the univariate analysis, significant prognostic factors included: age, portal vein thrombosis(PVT), size(>5cm) and type of tumor, response rate (size & -fetoprotein) at 3 months after therapy, level of albumin, alkaline phosphatase, and total bilirubin. After repeated therapy, Group I showed better survival (14.0 vs 7.9 months), but there was no statistical difference in survival rate between two groups in the case of large size, PVT, and diffuse type. CONCLUSION: Group I showed better survival than Group II in advanced HCC of TNM stage IVa. But, considering prognostic factors, there was no significant difference in survival rate between two groups except small size or nodular type of HCC. TNM classification of stage IVa should be reconsidered to include prognostic factors influencing survival rate such as PVT, size and type of HCC.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Lee, Kwan Sik(이관식) ORCID logo https://orcid.org/0000-0002-3672-1198
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