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Development of the lip and palate in staged human embryos and early fetuses

Authors
 Ho Yoon  ;  In Sun Chung  ;  Eun Young Seol  ;  Beyoung Yun Park  ;  Hyoung Woo Park 
Citation
 Yonsei Medical Journal, Vol.41(4) : 477-484, 2000 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
2000
MeSH
Female ; Gestational Age ; Humans ; Lip/embryology* ; Palate/embryology* ; Pregnancy
Keywords
Upper lip ; Lower lip ; palate ; human embryo ; fetus ; carnegie stage ; cleft lip ; cleft palate ; tongue
Abstract
Cleft lip and palate are the most common congenital malformations in humans. Using 43 staged human embryos and early fetuses ranging from the 4th to 12th week of development, we investigated the development of the lip and palate in order to provide the basic developmental concepts required for managing these anomalies. The lower lip appeared as bilateral mandibular arches at Carnegie stage 11, and these were completely merged at stage 15. The components of the upper lip, medial nasal prominence and maxillary process, appeared at stage 16, and completely merged at stage 20. The median palatine process appeared at stage 16, and the lateral palatine process, at stage 17. The palatine processes and the nasal septum started to fuse abruptly at stage 23, and from external observation seemed to be fused at the 9th week. However, complete fusion did not take place until the 12th week of development. The tongue was prominent at stage 16, showed differentiation of the muscular tissue at stage 21, and was located superior to the lateral palatine process before stage 23. These results may be used in understanding the different mechanisms present in the formation of various congenital anomalies in this region.
Files in This Item:
T200002811.pdf Download
DOI
10.3349/ymj.2000.41.4.477
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Park, Hyoung Woo(박형우) ORCID logo https://orcid.org/0000-0002-5341-9249
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171914
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