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Coexpression of cyclooxygenase-2 and matrix metalloproteinases in human aortic atherosclerotic lesions

 Bum Kee Hong  ;  Hyuck Moon Kwon  ;  Byoung Kwon Lee  ;  Dong Soo Kim  ;  In Jai Kim  ;  Seok-Min Kang  ;  YangSoo Jang  ;  Sang Ho Cho  ;  Hae Kyoon Kim  ;  Byung chul Jang  ;  Seung-Yun Cho  ;  Hyun-Seung Kim  ;  Myung Sin Kim  ;  Hyuck Chan Kwon  ;  Namho Lee 
 Yonsei Medical Journal, Vol.41(1) : 82-88, 2000 
Journal Title
Issue Date
Animals ; Aorta/enzymology* ; Aortic Diseases/enzymology* ; Aortic Diseases/pathology ; Arteriosclerosis/enzymology* ; Arteriosclerosis/pathology ; Cyclooxygenase 2 ; Female ; Guinea Pigs ; Humans ; Immunochemistry ; Isoenzymes/metabolism* ; Male ; Matrix Metalloproteinases/metabolism* ; Membrane Proteins ; Middle Aged ; Prostaglandin-Endoperoxide Synthases/metabolism*
Atherosclerosis ; cyclooxygenase-2 ; matrix metalloproteinase
Inflammation appears to have a major role in the development of atherosclerosis. Cyclooxygenase-2 (COX-2) is involved in the inflammatory response via the generation of prostanoids that, in turn, are involved in the production of matrix metalloproteinases (MMPs). This study aimed to investigate atherosclerosis in human aortas for in situ tissue distribution of COX-2, MMPs including MMP-9 and membrane type 1 MMP (MT1-MMP), and tissue inhibitor of metalloproteinase-2 (TIMP-2). Immunohistochemical studies were performed on atherosclerotic lesions of aortas from patients with aortic aneurysms (n = 4) and dissections (n = 3) by using antibodies to COX-2, MMP-9, MT1-MMP, and TIMP-2. Control tissues were obtained from traumatically dissected aortas (n = 2). All specimens from diseased aortas had atherosclerotic lesions ranging from fatty streak to atheromatous plaques. In control, there was no expression of COX-2, MMP-9, and MT1-MMP in all aortic layers. Immunoreactivity for COX-2 was predominantly noted in macrophages and smooth muscle cells (SMCs) of the intima including atherosclerotic plaque itself and the medial layer of the plaque base, as well as in SMCs and endothelial lining of the vasa vasorum in the adventitia. Immunoreactivity for MMP-9 and MT1-MMP was found in the same distribution as that of COX-2. Additionally, the expression of TIMP-2 increased in relation to MMP-9 expression. This study demonstrates that COX-2 is coexpressed with MMP-9 and MT1-MMP, not only by macrophages and SMCs in atherosclerotic lesions, but also in endothelial lining of the vasa vasorum of human aortas. Thus, vascular inflammatory reactions may influence extracellular matrix remodeling by coactivation of MMPs in the development of atherosclerosis and, in turn, the progression of disease
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Kwon, Hyuck Moon(권혁문) ORCID logo https://orcid.org/0000-0001-9901-5015
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