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Effect of Intermittent Administration of Parathyroid Hormone on Fracture Healing in Ovariectomized Rats

Authors
 Jun Seop Jahng  ;  Hyun Woo Kim 
Citation
 Orthopedics, Vol.23(10) : 1089-1094, 2000 
Journal Title
 Orthopedics 
ISSN
 0147-7447 
Issue Date
2000
MeSH
Animals ; Estradiol/pharmacology ; Female ; Fracture Fixation, Intramedullary ; Fracture Healing/drug effects* ; Ovariectomy* ; Parathyroid Hormone/administration & dosage* ; Rats ; Rats, Sprague-Dawley ; Recombinant Proteins/pharmacology ; Tibial Fractures/surgery
Abstract
The effects of intermittent administration of parathyroid hormone on fracture healing in ovariectomized rats were examined to evaluate its potential use as a therapeutic agent for osteoporotic fractures. Three months postovariectomy, bilateral tibial shaft fractures were induced and stabilized by intramedullary nailing with Kirschner wires. Saline, 17beta-estradiol (Sigma Chemical Corp, St Louis, Mo), or recombinant human parathyroid hormone (1-84) (Korean Green-Cross Pharm Corp, Seoul, Korea) was given once a day for 30 consecutive days during fracture healing. Fracture healing was assessed by morphometric and mechanical analysis of fracture callus. Intermittent parathyroid hormone administration increased the morphometric and mechanical parameters in a dose-dependent manner. A bone-resorption inhibiting agent, 17beta-estradiol did not offer advantage in terms of fracture healing in ovariectomized rats. Findings suggest intermittent parathyroid hormone administration may benefit osteoporosis and fracture.
Full Text
https://www.healio.com/orthopedics/journals/ortho/2000-10-23-10/%7B5209bc4b-ff5e-4e8b-aabe-001785364428%7D/effect-of-intermittent-administration-of-parathyroid-hormone-on-fracture-healing-in-ovariectomized-rats#divReadThis
DOI
10.3928/0147-7447-20001001-22
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyun Woo(김현우) ORCID logo https://orcid.org/0000-0001-8576-1877
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171836
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