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Effect of Intermittent Administration of Parathyroid Hormone on Fracture Healing in Ovariectomized Rats

DC FieldValueLanguage
dc.contributor.author김현우-
dc.date.accessioned2019-11-11T05:23:28Z-
dc.date.available2019-11-11T05:23:28Z-
dc.date.issued2000-
dc.identifier.issn0147-7447-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171836-
dc.description.abstractThe effects of intermittent administration of parathyroid hormone on fracture healing in ovariectomized rats were examined to evaluate its potential use as a therapeutic agent for osteoporotic fractures. Three months postovariectomy, bilateral tibial shaft fractures were induced and stabilized by intramedullary nailing with Kirschner wires. Saline, 17beta-estradiol (Sigma Chemical Corp, St Louis, Mo), or recombinant human parathyroid hormone (1-84) (Korean Green-Cross Pharm Corp, Seoul, Korea) was given once a day for 30 consecutive days during fracture healing. Fracture healing was assessed by morphometric and mechanical analysis of fracture callus. Intermittent parathyroid hormone administration increased the morphometric and mechanical parameters in a dose-dependent manner. A bone-resorption inhibiting agent, 17beta-estradiol did not offer advantage in terms of fracture healing in ovariectomized rats. Findings suggest intermittent parathyroid hormone administration may benefit osteoporosis and fracture.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSlack-
dc.relation.isPartOfOrthopedics-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnimals-
dc.subject.MESHEstradiol/pharmacology-
dc.subject.MESHFemale-
dc.subject.MESHFracture Fixation, Intramedullary-
dc.subject.MESHFracture Healing/drug effects*-
dc.subject.MESHOvariectomy*-
dc.subject.MESHParathyroid Hormone/administration & dosage*-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHRecombinant Proteins/pharmacology-
dc.subject.MESHTibial Fractures/surgery-
dc.titleEffect of Intermittent Administration of Parathyroid Hormone on Fracture Healing in Ovariectomized Rats-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Orthopedic Surgery (정형외과학교실)-
dc.contributor.googleauthorJun Seop Jahng-
dc.contributor.googleauthorHyun Woo Kim-
dc.identifier.doi10.3928/0147-7447-20001001-22-
dc.contributor.localIdA01124-
dc.relation.journalcodeJ03691-
dc.identifier.eissn1938-2367-
dc.identifier.pmid11045557-
dc.identifier.urlhttps://www.healio.com/orthopedics/journals/ortho/2000-10-23-10/%7B5209bc4b-ff5e-4e8b-aabe-001785364428%7D/effect-of-intermittent-administration-of-parathyroid-hormone-on-fracture-healing-in-ovariectomized-rats#divReadThis-
dc.contributor.alternativeNameKim, Hyun Woo-
dc.contributor.affiliatedAuthor김현우-
dc.citation.volume23-
dc.citation.number10-
dc.citation.startPage1089-
dc.citation.endPage1094-
dc.identifier.bibliographicCitationOrthopedics, Vol.23(10) : 1089-1094, 2000-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers

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