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Glucose/oxygen deprivation induces release of (3H)5-hydroxytryptamine associated with synapsin 1 expression in rat hippocampal slices

 Eunmi Park  ;  Sang Hui Chu  ;  KyungEun Lee 
 Korean Journal of Physiology & Pharmacology, Vol.4(5) : 347-353, 2000 
Journal Title
 Korean Journal of Physiology & Pharmacology 
Issue Date
Hippocampalslices ; Glucose/oxygendeprivation ; 5-Hydroxytryptamine ; Synapsin ; Syntaxin ; SNAP-25
It has been well documented that a massive release of not only glutamate but also other neurotransmitters may modulate the final responses of nerve cells to the ischemic neuronal injury. But there is no information regarding whether the release of monoamines is directly associated with synaptic vesicular proteins under ischemia. In the present study, it was investigated whether synapsin 1, syntaxin and SNAP-25 are involved in the release of 5-hydroxytryptamine ([3H]5-HT) in glucose/oxygen deprived (GOD) rat hippocampal slices. And, the effect of NMDA receptor using DL-2-amino-5-phosphonovaleric acid (APV) on ischemia- induced release of 5-HT and the changes of the above proteins were also investigated. GOD for 20 minutes enhanced release of [3H]5-HT, which was in part blocked by the NMDA receptor antagonist, APV. The augmented expression of synapsin 1 during GOD for 20 minutes, which was also in part prevented by APV. In contrast, the expression of syntaxin and SNAP-25 were not altered during GOD. These results suggest that ischemic insult induces release of [3H]5-HT associated with synapsin 1, synaptic vesicular protein, via activation of NMDA receptor in part.
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3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers
Yonsei Authors
Chu, Sang Hui(추상희) ORCID logo https://orcid.org/0000-0001-6877-5599
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