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Effect of IOP elevation on matrix metalloproteinase-2 in rabbit anterior chamber

Authors
 Chan-Yun Kim  ;  Sung Soo Kim  ;  Hyoung Jun Koh  ;  Yong Sung You  ;  Gong Je Seong  ;  Young Jae Hong 
Citation
 Korean Journal of Ophthalmology, Vol.14(1) : 27-31, 2000 
Journal Title
 Korean Journal of Ophthalmology 
ISSN
 1011-8942 
Issue Date
2000
MeSH
Animals ; Anterior Chamber/enzymology* ; Aqueous Humor/enzymology* ; Biomarkers ; Blotting, Western ; Intraocular Pressure* ; Matrix Metalloproteinase 2/metabolism* ; Ocular Hypertension/enzymology* ; Ocular Hypertension/etiology ; Rabbits ; Sclera/surgery ; Surgical Sponges/adverse effects
Keywords
Anterior chamber ; IOP ; MMP-2 ; rabbit
Abstract
To investigate changes in the level of matrix metalloproteinase-2 (MMP-2) in the anterior chamber of rabbit with intraocular pressure (IOP) elevation. The IOP was elevated with scleral encircling in 12 rabbits. In the control group (4 rabbits), IOP was not changed after scleral encircling, and in group 1 (4 rabbits) and 2 (4 rabbits), IOP was elevated about 10 and 20 mmHg respectively after scleral encircling. At 2 days after scleral encircling, aqueous sampling was performed and levels of MMP-2 were checked by Western blots and gelatin zymograms. The greater the IOP elevation, the more MMP-2 expression in the anterior chamber by Western blots and gelatin zymograms. The increase in MMP-2 expression in response to IOP elevation may have important implications for the IOP feedback control mechanism.
Files in This Item:
T200001631.pdf Download
DOI
10.3341/kjo.2000.14.1.27
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Seong, Gong Je(성공제) ORCID logo https://orcid.org/0000-0002-5456-4296
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171777
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