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동맥 혈전 모델에서 초음파와 Perfluorocarbon Exposed Sonicated Dextrose Albumin을 이용한 혈전 용해의 항진

Other Titles
 Enhancement of Thrombolytic Therapy by Transcutaneous Ultrasound and Perfluorocarbon Exposed Sonicated Dextrose Albumin in Thrombotic Arterial Occlusion. 
 임세중  ;  강석민  ;  하종원  ;  정광회  ;  장양수  ;  정남식 
 Korean Circulation Journal, Vol.30(5) : 621-628, 2000 
Journal Title
Issue Date
Thrombolytic effect ; Transcutaneous ultrasound ; Microbubbles
Background and Objectives:Perfluorocarbon exposed sonicated dextrose albumin (PESDA) microbubbles has been suggested to facilitate thrombus disruption under the transcutaneous ultrasound (US). Thus, we investigated whether such a noninvasive approach could augment thrombolytic effect of fibrinolytic agent in an experimental thrombotic model.
Materials and Methods:Thrombus formation was induced with electrical injury in the rabbit iliofemoral arteries (n=20);Thrombus occlusion was documented by angiography in all arteries. In the control group, only tissue plasminogen activator (t-PA, 3 mg/kg) was administered intravenously
in five rabbits. In the Group 1 (n=9), injured arteries were exposed to transcutaneous US (20 kHz, 30 W/cm 2 , continuous mode) with t-PA (3 mg/kg). In the Group 2 (n=6), the same treatment was given while administering PESDA continuously (10 ml/min, intravenous). Angiographic results were evaluated at 10 minute interval for 1 hour respectively.
Results:In the control group, two of five iliofemoral arteries (40.0%) were recanalized and one of nine iliofemoral arteries (11.1%) was recanalized in Group 1. In contrast, four of six iliofemoral arteries (66.7%) were recanalized angiographically in Group 2 (p=0.392 vs. control group;p=0.047 vs. Group 1). However, late reocclusion occurred in all iliofemoral arteries of Group 2.
Conclusion:Although PESDA with transcutaneous US significantly enhanced initial angiographic patency rate of t-PA, it was associated with high rate of reocclusion. Further studies will be necessary for clinical application of this noninvasive method in acute arterial occlusion. (Korean Circulation J 2000;30(5):621-628)
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
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