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동맥 혈전 모델에서 초음파와 Perfluorocarbon Exposed Sonicated Dextrose Albumin을 이용한 혈전 용해의 항진
DC Field | Value | Language |
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dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2019-11-11T05:17:03Z | - |
dc.date.available | 2019-11-11T05:17:03Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 1738-5520 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171755 | - |
dc.description.abstract | Background and Objectives:Perfluorocarbon exposed sonicated dextrose albumin (PESDA) microbubbles has been suggested to facilitate thrombus disruption under the transcutaneous ultrasound (US). Thus, we investigated whether such a noninvasive approach could augment thrombolytic effect of fibrinolytic agent in an experimental thrombotic model. Materials and Methods:Thrombus formation was induced with electrical injury in the rabbit iliofemoral arteries (n=20);Thrombus occlusion was documented by angiography in all arteries. In the control group, only tissue plasminogen activator (t-PA, 3 mg/kg) was administered intravenously in five rabbits. In the Group 1 (n=9), injured arteries were exposed to transcutaneous US (20 kHz, 30 W/cm 2 , continuous mode) with t-PA (3 mg/kg). In the Group 2 (n=6), the same treatment was given while administering PESDA continuously (10 ml/min, intravenous). Angiographic results were evaluated at 10 minute interval for 1 hour respectively. Results:In the control group, two of five iliofemoral arteries (40.0%) were recanalized and one of nine iliofemoral arteries (11.1%) was recanalized in Group 1. In contrast, four of six iliofemoral arteries (66.7%) were recanalized angiographically in Group 2 (p=0.392 vs. control group;p=0.047 vs. Group 1). However, late reocclusion occurred in all iliofemoral arteries of Group 2. Conclusion:Although PESDA with transcutaneous US significantly enhanced initial angiographic patency rate of t-PA, it was associated with high rate of reocclusion. Further studies will be necessary for clinical application of this noninvasive method in acute arterial occlusion. (Korean Circulation J 2000;30(5):621-628) | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English, Korean | - |
dc.publisher | Korean Society of Circulation | - |
dc.relation.isPartOf | Korean Circulation Journal | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 동맥 혈전 모델에서 초음파와 Perfluorocarbon Exposed Sonicated Dextrose Albumin을 이용한 혈전 용해의 항진 | - |
dc.title.alternative | Enhancement of Thrombolytic Therapy by Transcutaneous Ultrasound and Perfluorocarbon Exposed Sonicated Dextrose Albumin in Thrombotic Arterial Occlusion. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | 임세중 | - |
dc.contributor.googleauthor | 강석민 | - |
dc.contributor.googleauthor | 하종원 | - |
dc.contributor.googleauthor | 정광회 | - |
dc.contributor.googleauthor | 장양수 | - |
dc.contributor.googleauthor | 정남식 | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J01952 | - |
dc.identifier.eissn | 1738-5555 | - |
dc.subject.keyword | Thrombolytic effect | - |
dc.subject.keyword | Transcutaneous ultrasound | - |
dc.subject.keyword | Microbubbles | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | 장양수 | - |
dc.citation.volume | 30 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 621 | - |
dc.citation.endPage | 628 | - |
dc.identifier.bibliographicCitation | Korean Circulation Journal, Vol.30(5) : 621-628, 2000 | - |
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