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Distribution of P2X receptor subtypes in the rat female reproductive tract at late pro-oestrus/early oestrus.

Authors
 Michelle Bardini  ;  Hye Yeon Lee  ;  Geoffrey Burnstock 
Citation
 Journal of Physics D - Applied Physics, Vol.299(1) : 105-113, 2000 
Journal Title
 Journal of Physics D - Applied Physics 
ISSN
 0022-3727 
Issue Date
2000
MeSH
Amino Acid Sequence ; Animals ; Antibodies ; Cervix Uteri/cytology ; Cervix Uteri/physiology ; Endometrium/cytology ; Endometrium/physiology ; Estrus/physiology* ; Female ; Genitalia, Male/physiology ; Immunohistochemistry ; Male ; Molecular Sequence Data ; Muscle, Smooth/cytology ; Muscle, Smooth/physiology* ; Ovary/cytology ; Ovary/physiology* ; Peptide Fragments/chemistry ; Peptide Fragments/immunology ; Rats ; Rats, Sprague-Dawley ; Receptors, Purinergic P2/analysis ; Receptors, Purinergic P2/chemistry ; Receptors, Purinergic P2/metabolism* ; Uterus/cytology ; Uterus/physiology* ; Vagina/cytology ; Vagina/physiology*
Keywords
P2 receptor ; Immunohistochemistry ; Ovary ; Uterus ; Vagina ; Rat (Sprague Dawley)
Abstract
Using immunohistochemistry techniques, we have examined the female reproductive organs of the rat in late pro-oestrus/early oestrus for the presence of purine nucleotide P2X1-7 receptors. In contrast to the male genital organs and the urinary tract, P2X1 receptors were present weakly, if at all, on smooth muscle membranes, except in blood vessels, whereas P2X2 immunoreactivity in smooth muscle was present in ovary and uterus as well as in blood vessels. Neither P2X1 nor P2X2 receptors were present in fallopian tubes. P2X5 receptors were seen in the differentiating cell layers of the stratified squamous vaginal epithelium and also in the very early stages of ovarian follicular development; P2X6 receptors were present in secondary follicles. P2X7 receptors, markers for programmed cell death, were present in the keratinised vaginal epithelium and also in the exfoliating superficial endometrial cells. The possible biological significance of these signalling molecules in the female reproductive tract is discussed.
Full Text
https://link.springer.com/article/10.1007/s004419900138
DOI
10.1007/s004419900138
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Lee, Hye Yeon(이혜연) ORCID logo https://orcid.org/0000-0001-6945-1967
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171737
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