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Frequent frameshift mutations of RIZ in sporadic gastrointestinal and endometrial carcinomas with microsatellite instability

Authors
 Zhe Piao  ;  Wei Fang  ;  Sergei Malkhosyan  ;  Hoguen Kim  ;  Akira Horii  ;  Manuel Perucho  ;  Shi Huang 
Citation
 Journal of Neuroscience, Vol.60(17) : 4701-4704, 2000 
Journal Title
JOURNAL OF NEUROSCIENCE
ISSN
 0270-6474 
Issue Date
2000
MeSH
Alleles ; Colorectal Neoplasms/genetics* ; DNA-Binding Proteins* ; Endometrial Neoplasms/genetics* ; Female ; Frameshift Mutation/genetics* ; Gene Expression Regulation, Neoplastic ; Gene Silencing ; Histone-Lysine N-Methyltransferase ; Humans ; Microsatellite Repeats/genetics ; Nuclear Proteins/genetics* ; Stomach Neoplasms/genetics* ; Transcription Factors* ; Tumor Cells, Cultured ; Zinc Fingers/genetics*
Abstract
Many lines of evidence suggest that the retinoblastoma protein interacting zinc finger gene RIZ is a strong candidate for the tumor suppressor locus on 1p36, a region commonly deleted in many human cancers with chromosomal instability. In addition, a role for RIZ in tumors of the microsatellite instability pathway is suggested by frequent frameshift mutations in hereditary non-polyposis colorectal carcinomas. Here we studied RIZ mutations in sporadic cancers with microsatellite instability. Frameshift mutations in the two coding polyadenosine tracks of RIZ were found in 19 (48%) of 40 gastric carcinomas, 6 (33%) of 18 endometrial carcinomas, 14 (26%) of 51 of colorectal carcinomas, and 7 (54%) of 13 cell lines. Eleven tumor tissues showed biallelic inactivation of RIZ. In contrast, no frameshift mutations were found in 70 microsatellite stable tumors. These results suggest an important role for RIZ in sporadic cancers with microsatellite instability.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hogeun(김호근)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171727
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