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Frequent frameshift mutations of RIZ in sporadic gastrointestinal and endometrial carcinomas with microsatellite instability

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dc.contributor.author김호근-
dc.date.accessioned2019-11-11T05:14:53Z-
dc.date.available2019-11-11T05:14:53Z-
dc.date.issued2000-
dc.identifier.issn0270-6474-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171727-
dc.description.abstractMany lines of evidence suggest that the retinoblastoma protein interacting zinc finger gene RIZ is a strong candidate for the tumor suppressor locus on 1p36, a region commonly deleted in many human cancers with chromosomal instability. In addition, a role for RIZ in tumors of the microsatellite instability pathway is suggested by frequent frameshift mutations in hereditary non-polyposis colorectal carcinomas. Here we studied RIZ mutations in sporadic cancers with microsatellite instability. Frameshift mutations in the two coding polyadenosine tracks of RIZ were found in 19 (48%) of 40 gastric carcinomas, 6 (33%) of 18 endometrial carcinomas, 14 (26%) of 51 of colorectal carcinomas, and 7 (54%) of 13 cell lines. Eleven tumor tissues showed biallelic inactivation of RIZ. In contrast, no frameshift mutations were found in 70 microsatellite stable tumors. These results suggest an important role for RIZ in sporadic cancers with microsatellite instability.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherSociety for Neuroscience-
dc.relation.isPartOfJournal of Neuroscience-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAlleles-
dc.subject.MESHColorectal Neoplasms/genetics*-
dc.subject.MESHDNA-Binding Proteins*-
dc.subject.MESHEndometrial Neoplasms/genetics*-
dc.subject.MESHFemale-
dc.subject.MESHFrameshift Mutation/genetics*-
dc.subject.MESHGene Expression Regulation, Neoplastic-
dc.subject.MESHGene Silencing-
dc.subject.MESHHistone-Lysine N-Methyltransferase-
dc.subject.MESHHumans-
dc.subject.MESHMicrosatellite Repeats/genetics-
dc.subject.MESHNuclear Proteins/genetics*-
dc.subject.MESHStomach Neoplasms/genetics*-
dc.subject.MESHTranscription Factors*-
dc.subject.MESHTumor Cells, Cultured-
dc.subject.MESHZinc Fingers/genetics*-
dc.titleFrequent frameshift mutations of RIZ in sporadic gastrointestinal and endometrial carcinomas with microsatellite instability-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학교실)-
dc.contributor.googleauthorZhe Piao-
dc.contributor.googleauthorWei Fang-
dc.contributor.googleauthorSergei Malkhosyan-
dc.contributor.googleauthorHoguen Kim-
dc.contributor.googleauthorAkira Horii-
dc.contributor.googleauthorManuel Perucho-
dc.contributor.googleauthorShi Huang-
dc.contributor.localIdA01183-
dc.relation.journalcodeJ01633-
dc.identifier.eissn1529-2401-
dc.identifier.pmid10987271-
dc.contributor.alternativeNameKim, Ho Keun-
dc.contributor.affiliatedAuthor김호근-
dc.citation.volume60-
dc.citation.number17-
dc.citation.startPage4701-
dc.citation.endPage4704-
dc.identifier.bibliographicCitationJournal of Neuroscience, Vol.60(17) : 4701-4704, 2000-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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