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A systemic administration of NMDA induces immediate early gene pip92 in the hippocampus.

 Kwang Chul Chung  ;  Song Woo Shin  ;  Min Yoo  ;  Min Young Lee  ;  Hyun Woo Lee  ;  Byung Kil Choe  ;  Young Soo Ahn 
 Journal of Neurochemistry, Vol.75(1) : 9-17, 2000 
Journal Title
 Journal of Neurochemistry 
Issue Date
Animals ; Brain/metabolism ; Cell Line ; Cell Line, Transformed ; Enzyme Activation/drug effects ; Gene Expression/drug effects* ; Genes, Immediate-Early* ; Hippocampus/metabolism* ; Immediate-Early Proteins ; Injections, Intraperitoneal ; JNK Mitogen-Activated Protein Kinases* ; MAP Kinase Kinase 4 ; Mice ; Mice, Inbred ICR ; Mitogen-Activated Protein Kinase Kinases/metabolism ; Mitogen-Activated Protein Kinases/metabolism ; N-Methylaspartate/administration & dosage* ; Proteins/genetics* ; RNA, Messenger/analysis ; RNA, Messenger/biosynthesis ; Rats ; Stem Cells ; Tissue Distribution ; p38 Mitogen-Activated Protein Kinases
NMDA ; pip92 ; Excitotoxic injury ; c‐Jun N‐terminal kinase ; p38 ; Hippocampus.
In the mammalian CNS, aspartate and glutamate are major excitatory amino acids, and their receptors are believed to mediate a wide range of physiological and pathological processes, including neurotransmission, plasticity, excitotoxicity, and various forms of neurodegeneration. The immediate early gene pip92 has been identified in serum‐stimulated BALB/c 3T3 fibroblasts, activated T lymphocytes treated with cycloheximide, and fibroblast growth factor‐stimulated hippocampal cells during neuronal differentiation. In this study we have demonstrated that pip92 is expressed in the mouse brain after a single intraperitoneal injection of NMDA. The distribution of pip92 mRNA levels in the NMDA‐treated mouse brain was investigated using in situ RT‐PCR. The region‐specific activation of pip92 in the CNS was observed 3 h after NMDA injection, and high levels of pip92 mRNA were detected in the hippocampal dentate gyrus and piriform cortex regions. In addition, the activation of pip92 by NMDA was mediated by activation of mitogen‐activated protein kinases (MAPKs), such as c‐Jun N‐terminal kinase (JNK) and p38 kinase, but not extracellular signal‐regulated kinase (ERK) in the mouse hippocampus and immortalized rat hippocampal progenitor cells. This study suggests that pip92 is likely to play an important role in neuronal cell death induced by excitotoxic NMDA injury in the CNS.
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1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Ahn, Young Soo(안영수)
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