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Plasma granulocyte elastase levels and its relation to D-dimer in liver cirrhosis

Authors
 K.S. Song  ;  H.K. Kim  ;  H.S. Kim  ;  J.W. Song 
Citation
 Fibrinolysis and Proteolysis, Vol.14(5) : 300-304, 2000 
Journal Title
 Fibrinolysis and Proteolysis 
ISSN
 1369-0191 
Issue Date
2000
Abstract
Objective: Do plasma granulocyte elastase levels in liver cirrhosis influence D-dimer levels? Setting: University Hospital. Materials: We investigated plasma granulocyte elastase levels in 65 patients with liver cirrhosis and related it to D-dimer levels determined by enzyme linked immunoassay. Granulocyte elastase was carried out by heterogenous enzyme immunoassay using polymorphonuclear Elastase kit (Diagnostica Merck, Darmstadt, Germany). Results: The mean plasma levels of elastase (175.4 μg/l) and D-dimer (2732.7 μg/l) were significantly increased in patients with cirrhosis as compared to levels of normal subjects (elastase: 22 μg/l; D-dimer: 276 μg/l). There was no significant difference of elastase levels among Child classes (P =0.010) and etiology of cirrhosis (P =0.007). D-dimer levels were significantly different among different Child groups (P =0.020). Plasma elastase levels were positively correlated with D-dimer levels (r=0.437, P< 0.001). Conclusions: We have demonstrated a marked increase of granulocyte elastase and its relation to plasma D-dimer levels in patients with cirrhosis. This findings suggest that accelerated fibrinolysis in cirrhosis may be associated with cellular neutrophil activation and elevated granulocyte elastase level may be partially responsible for elevated D-dimer in cirrhosis.
Full Text
https://www.sciencedirect.com/science/article/pii/S0268949900900808
DOI
10.1054/fipr.2000.0080
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171634
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