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IgE immune response to Ginko biloba pollen.

 Yeong-Yeon Yun  ;  Si-Hwan Ko  ;  Jung-Won Park  ;  Chein-Soo Hong 
 Annals of Allergy, Asthma & Immunology, Vol.85(4) : 298-302, 2000 
Journal Title
 Annals of Allergy, Asthma & Immunology 
Issue Date
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antibodies, Anti-Idiotypic/blood ; Antibody Formation ; Asthma/diagnosis ; Child ; Cross Reactions/immunology ; Enzyme-Linked Immunosorbent Assay ; Ginkgo biloba/immunology* ; Humans ; Immunoblotting ; Immunoglobulin E/blood ; Immunoglobulin E/immunology* ; Middle Aged ; Plants, Medicinal* ; Pollen/immunology ; Protein Binding ; Skin Tests
Background The ginkgo (Ginkgo biloba L.) continues to be planted as a shade tree in preference to other species in Seoul, Korea. The proportion of ginkgo to total shade trees was 43.2% in 1998, but the allergenic characteristics of ginkgo pollen has not been elucidated. Objectives This study was undertaken to obtain information regarding the skin reactivity rate to ginkgo pollen in a population of Korean subjects with respiratory allergy. Possible ginkgo pollen allergens and the cross-reactivity of ginkgo pollen with other prevalent pollens were also examined. Methods Four hundred and forty-seven patients with asthma and/or allergic rhinitis were skin prick tested with extract of ginkgo pollen (1:20 wt/vol). Of these patients, positive skin responders (A/H ratio ≥2+) were selected for ELISA and immunoblot experiments. Results A total of 21 patients (4.7%) showed skin reactivity (A/H ratio ≥2+) to ginkgo pollen in the skin prick test. They were also cosensitized to many other tree, grass, and weed pollens. Sixteen (76%) of the 21 positive skin responders showed specific IgE responses to ginkgo pollen in ELISA. In inhibitory ELISA, IgE binding to ginkgo pollen was inhibited by more than 80% by oak, ryegrass, mugwort, and ragweed; and 34% by hop Japanese; and 10% by rBet v 2 at 10 μg/mL. In immunoblot, 10 out of 21 sera (48%) reacted to the 15-kD protein of ginkgo pollen, 9 (43%) to 33–35 kD, and 8 (38%) to 36–38 kD. In inhibitory immunoblot, IgE binding to ginkgo pollen proteins was almost completely inhibited by oak, ryegrass, mugwort and ragweed, but only partially by hop Japanese and rBet v 2. Conclusion The skin reactivity rate to ginkgo pollen is approximately 4.7% in a population of Korean subjects with respiratory allergy. Since ginkgo pollen has a high cross-reactivity with other prevalent pollens, it could cause clinical symptoms during its pollen season by cross-reacting with the IgE produced in response to other pollens in patients sensitized to multiple pollens.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Jung Won(박중원) ORCID logo https://orcid.org/0000-0003-0249-8749
Hong, Chein Soo(홍천수)
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