Cited 13 times in
IgE immune response to Ginko biloba pollen.
DC Field | Value | Language |
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dc.contributor.author | 박중원 | - |
dc.contributor.author | 홍천수 | - |
dc.date.accessioned | 2019-11-11T05:01:14Z | - |
dc.date.available | 2019-11-11T05:01:14Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 1081-1206 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171546 | - |
dc.description.abstract | Background The ginkgo (Ginkgo biloba L.) continues to be planted as a shade tree in preference to other species in Seoul, Korea. The proportion of ginkgo to total shade trees was 43.2% in 1998, but the allergenic characteristics of ginkgo pollen has not been elucidated. Objectives This study was undertaken to obtain information regarding the skin reactivity rate to ginkgo pollen in a population of Korean subjects with respiratory allergy. Possible ginkgo pollen allergens and the cross-reactivity of ginkgo pollen with other prevalent pollens were also examined. Methods Four hundred and forty-seven patients with asthma and/or allergic rhinitis were skin prick tested with extract of ginkgo pollen (1:20 wt/vol). Of these patients, positive skin responders (A/H ratio ≥2+) were selected for ELISA and immunoblot experiments. Results A total of 21 patients (4.7%) showed skin reactivity (A/H ratio ≥2+) to ginkgo pollen in the skin prick test. They were also cosensitized to many other tree, grass, and weed pollens. Sixteen (76%) of the 21 positive skin responders showed specific IgE responses to ginkgo pollen in ELISA. In inhibitory ELISA, IgE binding to ginkgo pollen was inhibited by more than 80% by oak, ryegrass, mugwort, and ragweed; and 34% by hop Japanese; and 10% by rBet v 2 at 10 μg/mL. In immunoblot, 10 out of 21 sera (48%) reacted to the 15-kD protein of ginkgo pollen, 9 (43%) to 33–35 kD, and 8 (38%) to 36–38 kD. In inhibitory immunoblot, IgE binding to ginkgo pollen proteins was almost completely inhibited by oak, ryegrass, mugwort and ragweed, but only partially by hop Japanese and rBet v 2. Conclusion The skin reactivity rate to ginkgo pollen is approximately 4.7% in a population of Korean subjects with respiratory allergy. Since ginkgo pollen has a high cross-reactivity with other prevalent pollens, it could cause clinical symptoms during its pollen season by cross-reacting with the IgE produced in response to other pollens in patients sensitized to multiple pollens. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | American College of Allergy, Asthma, and Immunology | - |
dc.relation.isPartOf | Annals of Allergy, Asthma & Immunology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | IgE immune response to Ginko biloba pollen. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Yeong-Yeon Yun | - |
dc.contributor.googleauthor | Si-Hwan Ko | - |
dc.contributor.googleauthor | Jung-Won Park | - |
dc.contributor.googleauthor | Chein-Soo Hong | - |
dc.identifier.doi | 10.1016/S1081-1206(10)62533-1 | - |
dc.contributor.localId | A01681 | - |
dc.contributor.localId | A04448-1 | - |
dc.relation.journalcode | J00153 | - |
dc.identifier.eissn | 1534-4436 | - |
dc.identifier.pmid | 11061473 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1081120610625331 | - |
dc.subject.keyword | Adolescent | - |
dc.subject.keyword | Adult | - |
dc.subject.keyword | Aged | - |
dc.subject.keyword | Aged, 80 and over | - |
dc.subject.keyword | Antibodies, Anti-Idiotypic/blood | - |
dc.subject.keyword | Antibody Formation | - |
dc.subject.keyword | Asthma/diagnosis | - |
dc.subject.keyword | Child | - |
dc.subject.keyword | Cross Reactions/immunology | - |
dc.subject.keyword | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.keyword | Ginkgo biloba/immunology* | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Immunoblotting | - |
dc.subject.keyword | Immunoglobulin E/blood | - |
dc.subject.keyword | Immunoglobulin E/immunology* | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Plants, Medicinal* | - |
dc.subject.keyword | Pollen/immunology | - |
dc.subject.keyword | Protein Binding | - |
dc.subject.keyword | Skin Tests | - |
dc.contributor.alternativeName | Park, Jung Won | - |
dc.contributor.affiliatedAuthor | 박중원 | - |
dc.contributor.affiliatedAuthor | 홍천수 | - |
dc.citation.volume | 85 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 298 | - |
dc.citation.endPage | 302 | - |
dc.identifier.bibliographicCitation | Annals of Allergy, Asthma & Immunology, Vol.85(4) : 298-302, 2000 | - |
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