60 89

Cited 27 times in

Serologic responses of Korean soldiers serving in malaria-endemic areas during a recent outbreak of Plasmodium vivax

Authors
 CHAE GYU PARK  ;  YONG-JOON CHWAE  ;  JONG-IL KIM  ;  JI-HO LEE GANG  ;  MIN HUR  ;  BYEONG HWA JEON  ;  JAE SOO KOH  ;  JAE-HEE HAN  ;  SHIN-JE LEE  ;  JAE-WON PARK  ;  DAVID C. KASLOW  ;  DANIEL STRICKMAN  ;  CHEON-SEOP ROH 
Citation
 American Journal of Tropical Medicine and Hygiene, Vol.62(6) : 720-725, 2000 
Journal Title
 American Journal of Tropical Medicine and Hygiene 
ISSN
 0002-9637 
Issue Date
2000
MeSH
Animals ; Antibodies, Protozoan/blood* ; Antigens, Protozoan/immunology ; Antigens, Surface/immunology ; Carrier State/parasitology ; DNA, Protozoan/analysis ; Disease Outbreaks* ; Endemic Diseases ; Humans ; Korea/epidemiology ; Malaria, Vivax/epidemiology* ; Malaria, Vivax/immunology* ; Malaria, Vivax/parasitology ; Military Personnel* ; Plasmodium vivax/genetics ; Plasmodium vivax/immunology* ; Plasmodium vivax/isolation & purification ; Polymerase Chain Reaction/methods ; Protozoan Proteins/immunology ; Seroepidemiologic Studies
Keywords
Animals ; Antibodies ; Protozoan ; blood ; Antigens ; Protozoan ; immunology ; Antigens ; Surface ; Carrier State ; parasitology ; DNA ; Protozoan ; analysis ; Disease Outbreaks ; Endemic Diseases ; Humans ; Korea ; epidemiology ; Malaria ; Vivax ; Military Personnel ; Plasmodium vivax ; genetics ; isolation & purification ; Polymerase Chain Reaction ; methods ; Protozoan Proteins ; Seroepidemiologic Studies
Abstract
Anti-Pv200 antibody levels were assessed in samples from endemic areas of Plasmodium vivax malaria in the Republic of Korea (ROK), using an indirect enzyme-linked immunosorbent assay (ELISA) method. Asymptomatic carriers of P. vivax were detected using nested polymerase chain reaction (PCR) of blood samples. Anti-Pv200 antibody levels in 20 vivax malaria patients (optical density +/- standard deviation [OD +/- SD] values 1.85 +/- 0.29 of IgG isotype and 1.33 +/- 1.33 of IgM isotype) were markedly higher than those of uninfected, malaria-naive controls (0.08 +/- 0.16 of IgG isotype and 0.04 +/- 0.04 of IgM isotype). Antibody levels for 7 out of 8 soldiers with a recent malaria infection were sustained above the cut-off values for 4 months after successful treatment. Analysis of serum collected from 40 healthy, asymptomatic soldiers who had a P. vivax malaria attack within 3 months after our sampling, revealed 11 antibody-positive samples (27.5%), compared to 5 positive samples (12.5%) collected from a random selection of 40 soldiers. Among a larger pool of 1,713 soldiers who had served in high-risk areas for P. vivax transmission, 15% were antibody positive. Among 1,000 blood samples from asymptomatic soldiers who had served in the high-risk areas, 4 samples (0.4%) were parasite positive, as determined by nested PCR. Our results show that anti-Pv200 antibody levels can provide useful information in the late diagnosis of P. vivax malaria infection in a previously naive population and also in large seroepidemiologic studies. Furthermore, our results suggest that asymptomatic P. vivax carriers could be important in the current outbreak of malaria in Korea.
Files in This Item:
T200003598.pdf Download
DOI
10.4269/ajtmh.2000.62.720
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Park, Chae Gyu(박채규) ORCID logo https://orcid.org/0000-0003-1906-1308
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171541
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links