Cited 29 times in
Serologic responses of Korean soldiers serving in malaria-endemic areas during a recent outbreak of Plasmodium vivax
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박채규 | - |
dc.date.accessioned | 2019-11-11T05:00:52Z | - |
dc.date.available | 2019-11-11T05:00:52Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 0002-9637 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171541 | - |
dc.description.abstract | Anti-Pv200 antibody levels were assessed in samples from endemic areas of Plasmodium vivax malaria in the Republic of Korea (ROK), using an indirect enzyme-linked immunosorbent assay (ELISA) method. Asymptomatic carriers of P. vivax were detected using nested polymerase chain reaction (PCR) of blood samples. Anti-Pv200 antibody levels in 20 vivax malaria patients (optical density +/- standard deviation [OD +/- SD] values 1.85 +/- 0.29 of IgG isotype and 1.33 +/- 1.33 of IgM isotype) were markedly higher than those of uninfected, malaria-naive controls (0.08 +/- 0.16 of IgG isotype and 0.04 +/- 0.04 of IgM isotype). Antibody levels for 7 out of 8 soldiers with a recent malaria infection were sustained above the cut-off values for 4 months after successful treatment. Analysis of serum collected from 40 healthy, asymptomatic soldiers who had a P. vivax malaria attack within 3 months after our sampling, revealed 11 antibody-positive samples (27.5%), compared to 5 positive samples (12.5%) collected from a random selection of 40 soldiers. Among a larger pool of 1,713 soldiers who had served in high-risk areas for P. vivax transmission, 15% were antibody positive. Among 1,000 blood samples from asymptomatic soldiers who had served in the high-risk areas, 4 samples (0.4%) were parasite positive, as determined by nested PCR. Our results show that anti-Pv200 antibody levels can provide useful information in the late diagnosis of P. vivax malaria infection in a previously naive population and also in large seroepidemiologic studies. Furthermore, our results suggest that asymptomatic P. vivax carriers could be important in the current outbreak of malaria in Korea. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | American Society of Tropical Medicine and Hygiene | - |
dc.relation.isPartOf | American Journal of Tropical Medicine and Hygiene | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antibodies, Protozoan/blood* | - |
dc.subject.MESH | Antigens, Protozoan/immunology | - |
dc.subject.MESH | Antigens, Surface/immunology | - |
dc.subject.MESH | Carrier State/parasitology | - |
dc.subject.MESH | DNA, Protozoan/analysis | - |
dc.subject.MESH | Disease Outbreaks* | - |
dc.subject.MESH | Endemic Diseases | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Korea/epidemiology | - |
dc.subject.MESH | Malaria, Vivax/epidemiology* | - |
dc.subject.MESH | Malaria, Vivax/immunology* | - |
dc.subject.MESH | Malaria, Vivax/parasitology | - |
dc.subject.MESH | Military Personnel* | - |
dc.subject.MESH | Plasmodium vivax/genetics | - |
dc.subject.MESH | Plasmodium vivax/immunology* | - |
dc.subject.MESH | Plasmodium vivax/isolation & purification | - |
dc.subject.MESH | Polymerase Chain Reaction/methods | - |
dc.subject.MESH | Protozoan Proteins/immunology | - |
dc.subject.MESH | Seroepidemiologic Studies | - |
dc.title | Serologic responses of Korean soldiers serving in malaria-endemic areas during a recent outbreak of Plasmodium vivax | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | BioMedical Science Institute (의생명과학부) | - |
dc.contributor.googleauthor | CHAE GYU PARK | - |
dc.contributor.googleauthor | YONG-JOON CHWAE | - |
dc.contributor.googleauthor | JONG-IL KIM | - |
dc.contributor.googleauthor | JI-HO LEE GANG | - |
dc.contributor.googleauthor | MIN HUR | - |
dc.contributor.googleauthor | BYEONG HWA JEON | - |
dc.contributor.googleauthor | JAE SOO KOH | - |
dc.contributor.googleauthor | JAE-HEE HAN | - |
dc.contributor.googleauthor | SHIN-JE LEE | - |
dc.contributor.googleauthor | JAE-WON PARK | - |
dc.contributor.googleauthor | DAVID C. KASLOW | - |
dc.contributor.googleauthor | DANIEL STRICKMAN | - |
dc.contributor.googleauthor | CHEON-SEOP ROH | - |
dc.identifier.doi | 10.4269/ajtmh.2000.62.720 | - |
dc.contributor.localId | A01718 | - |
dc.relation.journalcode | J00122 | - |
dc.identifier.eissn | 1476-1645 | - |
dc.identifier.pmid | 11304063 | - |
dc.subject.keyword | Animals | - |
dc.subject.keyword | Antibodies | - |
dc.subject.keyword | Protozoan | - |
dc.subject.keyword | blood | - |
dc.subject.keyword | Antigens | - |
dc.subject.keyword | Protozoan | - |
dc.subject.keyword | immunology | - |
dc.subject.keyword | Antigens | - |
dc.subject.keyword | Surface | - |
dc.subject.keyword | Carrier State | - |
dc.subject.keyword | parasitology | - |
dc.subject.keyword | DNA | - |
dc.subject.keyword | Protozoan | - |
dc.subject.keyword | analysis | - |
dc.subject.keyword | Disease Outbreaks | - |
dc.subject.keyword | Endemic Diseases | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Korea | - |
dc.subject.keyword | epidemiology | - |
dc.subject.keyword | Malaria | - |
dc.subject.keyword | Vivax | - |
dc.subject.keyword | Military Personnel | - |
dc.subject.keyword | Plasmodium vivax | - |
dc.subject.keyword | genetics | - |
dc.subject.keyword | isolation & purification | - |
dc.subject.keyword | Polymerase Chain Reaction | - |
dc.subject.keyword | methods | - |
dc.subject.keyword | Protozoan Proteins | - |
dc.subject.keyword | Seroepidemiologic Studies | - |
dc.contributor.alternativeName | Park, Chae Gyu | - |
dc.contributor.affiliatedAuthor | 박채규 | - |
dc.citation.volume | 62 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 720 | - |
dc.citation.endPage | 725 | - |
dc.identifier.bibliographicCitation | American Journal of Tropical Medicine and Hygiene, Vol.62(6) : 720-725, 2000 | - |
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