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Increase in 24-Hour Protein Excretion Immediately After Donation Is Associated With Decreased Functional Recovery in Living Kidney Donors

Authors
 Joon Chae Na  ;  Min-Gee Yoon  ;  Hyung Ho Lee  ;  Young Eun Yoon  ;  Deok Gie Kim  ;  Kyu Ha Huh  ;  Yu Seun Kim  ;  Woong Kyu Han 
Citation
 Transplantation Proceedings, Vol.51(8) : 2543-2548, 2019 
Journal Title
 Transplantation Proceedings 
ISSN
 0041-1345 
Issue Date
2019
Abstract
OBJECTIVES: In this study, we evaluated the occurrence of proteinuria in living kidney donors during the immediate postdonation period, aiming to determine its clinical significance in renal function recovery. PATIENTS AND METHODS: We enrolled living kidney donors with predonation protein excretion rate (PER) < 150 mg/24 h. Participants were divided into 2 groups according to immediate postdonation PER (4 days after nephrectomy): non-microproteinuria (non-mPr; PER < 150 mg/24 h), n = 244; and immediate postdonation microproteinuria (ImPr; PER ≥ 150 mg/24 h), n = 605. RESULTS: Estimated glomerular filtration rate (eGFR) did not differ significantly between groups immediately after nephrectomy but was consistently lower in the ImPr group 1 week to 1 year postdonation (1-year postdonation eGFR: ImPr group, 63.6 ± 12.1 mL/min/1.73 m2; non-mPr group, 68.6 ± 12.3 mL/min/1.73 m2; P = .001). Immediate postdonation microproteinuria was an independent predictor of eGFR at 1 year postdonation (β [standard error] = -2.68 [1.15], 95% confidence interval -4.94 to -0.42, P = .02), along with predonation eGFR, age, and sex. Immediate postdonation microproteinuria was more common in donors who were older or male and occurred in 71.3% of kidney donors, suggesting renal injury in this period. CONCLUSIONS: Although proteinuria generally resolves, its impact persists and can impair renal function recovery. Donors who are older and male are more likely to undergo immediate hyperfiltration after donation.
Full Text
https://www.sciencedirect.com/science/article/pii/S0041134519302817?via%3Dihub
DOI
10.1016/j.transproceed.2019.03.081
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Deok Gie(김덕기)
Kim, Yu Seun(김유선) ORCID logo https://orcid.org/0000-0002-5105-1567
Na, Joon Chae(나준채) ORCID logo https://orcid.org/0000-0003-4449-8472
Han, Woong Kyu(한웅규) ORCID logo https://orcid.org/0000-0002-2527-4046
Huh, Kyu Ha(허규하) ORCID logo https://orcid.org/0000-0003-1364-6989
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171507
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