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Increase in 24-Hour Protein Excretion Immediately After Donation Is Associated With Decreased Functional Recovery in Living Kidney Donors
DC Field | Value | Language |
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dc.contributor.author | 김유선 | - |
dc.contributor.author | 한웅규 | - |
dc.contributor.author | 허규하 | - |
dc.contributor.author | 나준채 | - |
dc.contributor.author | 김덕기 | - |
dc.date.accessioned | 2019-10-28T02:08:52Z | - |
dc.date.available | 2019-10-28T02:08:52Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0041-1345 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171507 | - |
dc.description.abstract | OBJECTIVES: In this study, we evaluated the occurrence of proteinuria in living kidney donors during the immediate postdonation period, aiming to determine its clinical significance in renal function recovery. PATIENTS AND METHODS: We enrolled living kidney donors with predonation protein excretion rate (PER) < 150 mg/24 h. Participants were divided into 2 groups according to immediate postdonation PER (4 days after nephrectomy): non-microproteinuria (non-mPr; PER < 150 mg/24 h), n = 244; and immediate postdonation microproteinuria (ImPr; PER ≥ 150 mg/24 h), n = 605. RESULTS: Estimated glomerular filtration rate (eGFR) did not differ significantly between groups immediately after nephrectomy but was consistently lower in the ImPr group 1 week to 1 year postdonation (1-year postdonation eGFR: ImPr group, 63.6 ± 12.1 mL/min/1.73 m2; non-mPr group, 68.6 ± 12.3 mL/min/1.73 m2; P = .001). Immediate postdonation microproteinuria was an independent predictor of eGFR at 1 year postdonation (β [standard error] = -2.68 [1.15], 95% confidence interval -4.94 to -0.42, P = .02), along with predonation eGFR, age, and sex. Immediate postdonation microproteinuria was more common in donors who were older or male and occurred in 71.3% of kidney donors, suggesting renal injury in this period. CONCLUSIONS: Although proteinuria generally resolves, its impact persists and can impair renal function recovery. Donors who are older and male are more likely to undergo immediate hyperfiltration after donation. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science Inc. | - |
dc.relation.isPartOf | Transplantation Proceedings | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Increase in 24-Hour Protein Excretion Immediately After Donation Is Associated With Decreased Functional Recovery in Living Kidney Donors | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Joon Chae Na | - |
dc.contributor.googleauthor | Min-Gee Yoon | - |
dc.contributor.googleauthor | Hyung Ho Lee | - |
dc.contributor.googleauthor | Young Eun Yoon | - |
dc.contributor.googleauthor | Deok Gie Kim | - |
dc.contributor.googleauthor | Kyu Ha Huh | - |
dc.contributor.googleauthor | Yu Seun Kim | - |
dc.contributor.googleauthor | Woong Kyu Han | - |
dc.identifier.doi | 10.1016/j.transproceed.2019.03.081 | - |
dc.contributor.localId | A00785 | - |
dc.contributor.localId | A04308 | - |
dc.contributor.localId | A04344 | - |
dc.contributor.localId | A04742 | - |
dc.contributor.localId | A05303 | - |
dc.relation.journalcode | J02755 | - |
dc.identifier.eissn | 1873-2623 | - |
dc.identifier.pmid | 31473006 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0041134519302817?via%3Dihub | - |
dc.contributor.alternativeName | Kim, Yu Seun | - |
dc.contributor.affiliatedAuthor | 김유선 | - |
dc.contributor.affiliatedAuthor | 한웅규 | - |
dc.contributor.affiliatedAuthor | 허규하 | - |
dc.contributor.affiliatedAuthor | 나준채 | - |
dc.contributor.affiliatedAuthor | 김덕기 | - |
dc.citation.volume | 51 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 2543 | - |
dc.citation.endPage | 2548 | - |
dc.identifier.bibliographicCitation | Transplantation Proceedings, Vol.51(8) : 2543-2548, 2019 | - |
dc.identifier.rimsid | 63764 | - |
dc.type.rims | ART | - |
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