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Increase in 24-Hour Protein Excretion Immediately After Donation Is Associated With Decreased Functional Recovery in Living Kidney Donors

DC FieldValueLanguage
dc.contributor.author김유선-
dc.contributor.author한웅규-
dc.contributor.author허규하-
dc.contributor.author나준채-
dc.contributor.author김덕기-
dc.date.accessioned2019-10-28T02:08:52Z-
dc.date.available2019-10-28T02:08:52Z-
dc.date.issued2019-
dc.identifier.issn0041-1345-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171507-
dc.description.abstractOBJECTIVES: In this study, we evaluated the occurrence of proteinuria in living kidney donors during the immediate postdonation period, aiming to determine its clinical significance in renal function recovery. PATIENTS AND METHODS: We enrolled living kidney donors with predonation protein excretion rate (PER) < 150 mg/24 h. Participants were divided into 2 groups according to immediate postdonation PER (4 days after nephrectomy): non-microproteinuria (non-mPr; PER < 150 mg/24 h), n = 244; and immediate postdonation microproteinuria (ImPr; PER ≥ 150 mg/24 h), n = 605. RESULTS: Estimated glomerular filtration rate (eGFR) did not differ significantly between groups immediately after nephrectomy but was consistently lower in the ImPr group 1 week to 1 year postdonation (1-year postdonation eGFR: ImPr group, 63.6 ± 12.1 mL/min/1.73 m2; non-mPr group, 68.6 ± 12.3 mL/min/1.73 m2; P = .001). Immediate postdonation microproteinuria was an independent predictor of eGFR at 1 year postdonation (β [standard error] = -2.68 [1.15], 95% confidence interval -4.94 to -0.42, P = .02), along with predonation eGFR, age, and sex. Immediate postdonation microproteinuria was more common in donors who were older or male and occurred in 71.3% of kidney donors, suggesting renal injury in this period. CONCLUSIONS: Although proteinuria generally resolves, its impact persists and can impair renal function recovery. Donors who are older and male are more likely to undergo immediate hyperfiltration after donation.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier Science Inc.-
dc.relation.isPartOfTransplantation Proceedings-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleIncrease in 24-Hour Protein Excretion Immediately After Donation Is Associated With Decreased Functional Recovery in Living Kidney Donors-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorJoon Chae Na-
dc.contributor.googleauthorMin-Gee Yoon-
dc.contributor.googleauthorHyung Ho Lee-
dc.contributor.googleauthorYoung Eun Yoon-
dc.contributor.googleauthorDeok Gie Kim-
dc.contributor.googleauthorKyu Ha Huh-
dc.contributor.googleauthorYu Seun Kim-
dc.contributor.googleauthorWoong Kyu Han-
dc.identifier.doi10.1016/j.transproceed.2019.03.081-
dc.contributor.localIdA00785-
dc.contributor.localIdA04308-
dc.contributor.localIdA04308-
dc.contributor.localIdA04344-
dc.contributor.localIdA04344-
dc.contributor.localIdA04742-
dc.contributor.localIdA04742-
dc.contributor.localIdA05303-
dc.contributor.localIdA05303-
dc.relation.journalcodeJ02755-
dc.identifier.eissn1873-2623-
dc.identifier.pmid31473006-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0041134519302817?via%3Dihub-
dc.contributor.alternativeNameKim, Yu Seun-
dc.contributor.affiliatedAuthor김유선-
dc.contributor.affiliatedAuthor한웅규-
dc.contributor.affiliatedAuthor한웅규-
dc.contributor.affiliatedAuthor허규하-
dc.contributor.affiliatedAuthor허규하-
dc.contributor.affiliatedAuthor나준채-
dc.contributor.affiliatedAuthor나준채-
dc.contributor.affiliatedAuthor김덕기-
dc.contributor.affiliatedAuthor김덕기-
dc.citation.volume51-
dc.citation.number8-
dc.citation.startPage2543-
dc.citation.endPage2548-
dc.identifier.bibliographicCitationTransplantation Proceedings, Vol.51(8) : 2543-2548, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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