Purpose: The purpose of this study was to explore uncertainty, depression, and anxiety in isolated inpatients and
to identify associations between them, with specific focus on state anxiety. Methods: Data were collected using structured
questionnaires and semi-structured interviews, administered to isolated inpatients at an acute care hospital
(N=92). The structured questionnaires consisted of the State-Trait Anxiety Inventory, Mishel Uncertainty in Illness
Scale, and the Center for Epidemiologic Studies Depression Scale. Multiple linear regression and content analysis
were conducted. Results: Isolated inpatients showed significant differences in uncertainty, depression, trait anxiety,
and state anxiety according to gender, perception of sufficient information about isolation, and the type of isolation.
State anxiety scores increased when sufficient information about isolation was not provided (β=.23, p=.005), with
higher levels of depression (β=.24, p=.020) and trait anxiety (β=.49, p<.001). Through the content analysis, three
themes were identified regarding patient’s information needs about isolation specifically for disease, explanation,
and environment. Conclusion: Based on the findings, it is crucial to improve the awareness of emotional responses
of isolated patients experiencing uncertainty, depression, and anxiety. Our study findings are expected to support
the development of nursing interventions to provide proper information and mental health support when caring for
isolated inpatients.