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Delta Neutrophil Index for the Prediction of the Development of Sepsis-Induced Acute Kidney Injury in the Emergency Department

DC Field Value Language
dc.contributor.author공태영-
dc.contributor.author박유석-
dc.contributor.author유제성-
dc.contributor.author윤창연-
dc.contributor.author이혜선-
dc.contributor.author정성필-
dc.contributor.author김시내-
dc.contributor.author김지훈-
dc.date.accessioned2019-10-28T01:58:50Z-
dc.date.available2019-10-28T01:58:50Z-
dc.date.issued2019-
dc.identifier.issn1073-2322-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171430-
dc.description.abstractBACKGROUND AND PURPOSE: The early prediction of acute kidney injury (AKI) in sepsis and provision of timely treatment may improve outcomes. We investigated the efficacy of the delta neutrophil index (DNI)-which reflects the fraction of immature granulocytes-in predicting sepsis-induced AKI and 30-day mortality in cases of severe sepsis or septic shock. METHODS: This retrospective, observational cohort study was performed with patients prospectively integrated in a critical pathway of early-goal-directed therapy /SEPSIS. We analyzed adult sepsis patients admitted to the emergency department with normal kidney function or stage 1 disease, based on the Acute Kidney Injury Network classification, between January 1, 2014 and September 30, 2017. The outcomes were the development of sepsis-induced severe AKI within 7 days and 30-day mortality. RESULTS: A total of 346 patients were enrolled. An increase in the DNI values at Time-0 (odds ratio [OR], 1.060; P < 0.001) and Time-12 (OR, 1.086; P < 0.001) were strong independent predictors of severe AKI development. The increasing predictability of AKI was closely associated with a DNI ≥14.0% at Time-0 (OR, 7.238; P < 0.001) and ≥13.3% at Time-12 (OR, 18.089; P < 0.001). The development of severe AKI was an independent predictor of 30-day mortality (hazard ratio: 25.2, P < 0.001). CONCLUSION: Higher DNI values are independent predictors of severe AKI development and 30-day mortality in sepsis. Physicians can use the DNI to quickly determine the severity of sepsis and initial treatment strategies without additional costs and effort.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfShock-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleDelta Neutrophil Index for the Prediction of the Development of Sepsis-Induced Acute Kidney Injury in the Emergency Department-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Emergency Medicine (응급의학교실)-
dc.contributor.googleauthorKim, Ji Hoon-
dc.contributor.googleauthorPark, Yoo Seok-
dc.contributor.googleauthorYoon, Chang-Yun-
dc.contributor.googleauthorLee, Hye Sun-
dc.contributor.googleauthorKim, Sinae-
dc.contributor.googleauthorLee, Jong Wook-
dc.contributor.googleauthorKong, Taeyoung-
dc.contributor.googleauthorYou, Je Sung-
dc.contributor.googleauthorPark, Jong Woo-
dc.contributor.googleauthorChung, Sung Phil-
dc.identifier.doi10.1097/SHK.0000000000001299-
dc.contributor.localIdA00162-
dc.contributor.localIdA01592-
dc.contributor.localIdA02507-
dc.contributor.localIdA02613-
dc.contributor.localIdA03312-
dc.contributor.localIdA03625-
dc.contributor.localIdA05313-
dc.contributor.localIdA05321-
dc.relation.journalcodeJ02658-
dc.identifier.eissn1540-0514-
dc.identifier.pmid30883453-
dc.identifier.urlhttps://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00024382-201910000-00004&D=ovft&PDF=y-
dc.contributor.alternativeNameKong, Tae Young-
dc.contributor.affiliatedAuthor공태영-
dc.contributor.affiliatedAuthor박유석-
dc.contributor.affiliatedAuthor유제성-
dc.contributor.affiliatedAuthor윤창연-
dc.contributor.affiliatedAuthor이혜선-
dc.contributor.affiliatedAuthor정성필-
dc.contributor.affiliatedAuthor김시내-
dc.contributor.affiliatedAuthor김지훈-
dc.citation.volume52-
dc.citation.number4-
dc.citation.startPage414-
dc.citation.endPage422-
dc.identifier.bibliographicCitationShock, Vol.52(4) : 414-422, 2019-
dc.identifier.rimsid63712-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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