0 113

Cited 2 times in

Dedifferentiated Schwann cells secrete progranulin that enhances the survival and axon growth of motor neurons

Authors
 Sujin Hyung  ;  Sun‐Kyoung Im  ;  Bo Yoon Lee  ;  Jihye Shin  ;  Jong‐Chul Park  ;  Cheolju Lee  ;  Jun‐Kyo Francis Suh  ;  Eun‐Mi Hur 
Citation
 Glia, Vol.67(2) : 360-375, 2019 
Journal Title
 Glia 
ISSN
 0894-1491 
Issue Date
2019
MeSH
Animals ; Axons/drug effects ; Axons/pathology* ; Bucladesine/pharmacology ; Cell Proliferation/drug effects* ; Cell Survival/drug effects ; Cells, Cultured ; Coculture Techniques ; Culture Media, Conditioned/pharmacology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Fluoresceins/metabolism ; Mass Spectrometry ; Mice ; Mice, Inbred ICR ; Motor Neurons/drug effects ; Motor Neurons/pathology* ; Progranulins/metabolism* ; Progranulins/pharmacology ; RNA, Messenger/metabolism ; Schwann Cells/chemistry ; Schwann Cells/metabolism* ; Sciatic Neuropathy/pathology* ; Spinal Cord/cytology
Keywords
Schwann cells ; dedifferentiation ; motor neurons ; progranulin ; secretion
Abstract
Schwann cells (SCs), the primary glia in the peripheral nervous system (PNS), display remarkable plasticity in that fully mature SCs undergo dedifferentiation and convert to repair SCs upon nerve injury. Dedifferentiated SCs provide essential support for PNS regeneration by producing signals that enhance the survival and axon regrowth of damaged neurons, but the identities of neurotrophic factors remain incompletely understood. Here we show that SCs express and secrete progranulin (PGRN), depending on the differentiation status of SCs. PGRN expression and secretion markedly increased as primary SCs underwent dedifferentiation, while PGRN secretion was prevented by administration of cAMP, which induced SC differentiation. We also found that sciatic nerve injury, a physiological trigger of SC dedifferentiation, induced PGRN expression in SCs in vivo. These results suggest that dedifferentiated SCs express and secrete PGRN that functions as a paracrine factor to support the survival and axon growth of neighboring neurons after injury.
Full Text
https://onlinelibrary.wiley.com/doi/full/10.1002/glia.23547
DOI
10.1002/glia.23547
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171396
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links