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Association between Therapeutic Alliance and Adherence in Outpatient Schizophrenia Patients

 Jhin Goo Chang  ;  Daeyoung Roh  ;  Chan-Hyung Kim 
 Clinical Psychopharmacology and Neuroscience, Vol.17(2) : 273-278, 2019 
Journal Title
 Clinical Psychopharmacology and Neuroscience 
Issue Date
Medication adherence ; Physician-patient relations ; Schizophrenia
Objective: Although various clinical factors that affect medication adherence in schizophrenia have been studied, the role of the therapeutic alliance has not been studied in detail. Accordingly, we investigated the association between medication adherence and therapeutic alliance in patients with schizophrenia treated in a community outpatient clinic in Korea. Methods: In this cross-sectional study, 81 outpatients who met the DSM-IV-TR criteria for schizophrenia were analyzed. Therapeutic alliance was measured via patient-self-report questionnaires consisting of 12 questions, which evaluate both affective bond and collaborative bond of alliance. We investigated the relationship between medication adherence and therapeutic alliance through correlation and regression analyses. Results: Overall therapeutic alliance was weakly associated with medication adherence (r=0.268, p<0.05). Among two factors of therapeutic alliance, affective bond was associated with adherence (r=0.302, p<0.05), but collaborative was not. Regression analysis showed that therapeutic alliance significantly predicted medication adherence even after adjustment for duration of treatment, insight, and symptom severity. Conclusion: Maintaining a favorable therapeutic alliance is associated with medication adherence in schizophrenia. Further, treating patients in a frank and genuine manner might be important to improve adherence.
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1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chan Hyung(김찬형)
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