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Whole-exome and whole-transcriptome sequencing of canine mammary gland tumors

Authors
 Ka-Kyung Kim  ;  Byung-Joon Seung  ;  Dohyun Kim  ;  Hee-Myung Park  ;  Sejoon Lee  ;  Doo-Won Song  ;  Gunho Lee  ;  Jae-Ho Cheong  ;  Hojung Nam  ;  Jung-Hyang Sur  ;  Sangwoo Kim 
Citation
 Scientific Data, Vol.6(1) : 147, 2019 
Journal Title
 Scientific Data 
Issue Date
2019
Abstract
Studies of naturally occurring cancers in dogs, which share many genetic and environmental factors with humans, provide valuable information as a comparative model for studying the mechanisms of human cancer pathogenesis. While individual and small-scale studies of canine cancers are underway, more generalized multi-omics studies have not been attempted due to the lack of large-scale and well-controlled genomic data. Here, we produced reliable whole-exome and whole-transcriptome sequencing data of 197 canine mammary cancers and their matched controls, annotated with rich clinical and biological features. Our dataset provides useful reference points for comparative analysis with human cancers and for developing novel diagnostic and therapeutic technologies for cancers in pet dogs.
Files in This Item:
T201903440.pdf Download
DOI
10.1038/s41597-019-0149-8
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sangwoo(김상우) ORCID logo https://orcid.org/0000-0001-5356-0827
Cheong, Jae Ho(정재호) ORCID logo https://orcid.org/0000-0002-1703-1781
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171371
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