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Decellularized human periodontal ligament for periodontium regeneration

DC Field Value Language
dc.contributor.author송제선-
dc.contributor.author최형준-
dc.contributor.author강정민-
dc.contributor.author전미정-
dc.date.accessioned2019-10-28T01:51:21Z-
dc.date.available2019-10-28T01:51:21Z-
dc.date.issued2019-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171367-
dc.description.abstractRegenerating the periodontal ligament (PDL) is a crucial factor for periodontal tissue regeneration in the presence of traumatized and periodontally damaged teeth. Various methods have been applied for periodontal regeneration, including tissue substitutes, bioactive materials, and synthetic scaffolds. However, all of these treatments have had limited success in structural and functional periodontal tissue regeneration. To achieve the goal of complete periodontal regeneration, many studies have evaluated the effectiveness of decellularized scaffolds fabricated via tissue engineering. The aim of this study was to fabricate a decellularized periodontal scaffold of human tooth slices and determine its regeneration potential. We evaluated two different protocols applied to tooth slices obtained from human healthy third molars. The extracellular matrix scaffold decellularized using sodium dodecyl sulfate and Triton X-100, which are effective in removing nuclear components, was demonstrated to preserve an intact structure and composition. Furthermore, the decellularized scaffold could support repopulation of PDL stem cells near the cementum and expressed cementum and periodontal-ligament-related genes. These results show that decellularized PDL scaffolds of human teeth are capable of inducing the proliferation and differentiation of mesenchymal stem cells, thus having regeneration potential for use in future periodontal regenerative tissue engineering.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLoS One-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleDecellularized human periodontal ligament for periodontium regeneration-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Pediatric Dentistry (소아치과학교실)-
dc.contributor.googleauthorHyoju Son-
dc.contributor.googleauthorMijeong Jeon-
dc.contributor.googleauthorHyung-Jun Choi-
dc.contributor.googleauthorHyo-Seol Lee-
dc.contributor.googleauthorIk-Hwan Kim-
dc.contributor.googleauthorChung-Min Kang-
dc.contributor.googleauthorJe Seon Song-
dc.identifier.doi10.1371/journal.pone.0221236-
dc.contributor.localIdA02058-
dc.contributor.localIdA04216-
dc.contributor.localIdA05078-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid31415652-
dc.contributor.alternativeNameSong, Je Seon-
dc.contributor.affiliatedAuthor송제선-
dc.contributor.affiliatedAuthor최형준-
dc.contributor.affiliatedAuthor강정민-
dc.citation.volume14-
dc.citation.number8-
dc.citation.startPagee0221236-
dc.identifier.bibliographicCitationPLoS One, Vol.14(8) : e0221236, 2019-
dc.identifier.rimsid63898-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Research Institute (부설연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Pediatric Dentistry (소아치과학교실) > 1. Journal Papers

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