86 124

Cited 3 times in

Associated Factors and Clinical Implication of Cutaneous Allodynia in Patients with Cluster Headache: A Prospective Multicentre Study

 Byung-Su Kim  ;  Jeong Wook Park  ;  Jong-Hee Sohn  ;  Mi Ji Lee  ;  Byung-Kun Kim  ;  Min Kyung Chu  ;  Jin-Young Ahn  ;  Yun-Ju Choi  ;  Tae-Jin Song  ;  Pil-Wook Chung  ;  Kyungmi Oh  ;  Kwang-Soo Lee  ;  Soo-Kyoung Kim  ;  Kwang-Yeol Park  ;  Jae Myun Chung  ;  Heui-Soo Moon  ;  Chin-Sang Chung  ;  Soo-Jin Cho 
 Scientific Reports, Vol.9(1) : 6548, 2019 
Journal Title
 Scientific Reports 
Issue Date
Cutaneous allodynia (CA) is an abnormal pain in response to non-painful stimuli. In the present study, we sought to investigate the presence of CA, its associated factors, and its clinical implications in patients with cluster headache (CH). In this cross-sectional study, we analysed data from a prospective multicentre registry enrolling consecutive patients with CH. We identified CA during and between headache attacks using the 12-item Allodynia Symptom Checklist (ASC) administered during the CH bout period. Comorbid depression and anxiety were ascertained using the Patient Health Questionnaire (PHQ-9) and the Generalized Anxiety Disorder (GAD-7) scales. Headache impact was evaluated using the Headache Impact Test-6 (HIT-6). Of 119 eligible patients, 48 and two (40.3% and 1.7%) had CA during and between headache attacks, respectively. In univariable analyses, total CH duration, major depressive disorder (MDD), and generalized anxiety disorder (GAD) were associated with CA during headache attack. They remained significantly associated with CA during headache attack in multivariable analyses. Patients with CA during headache attack had higher headache impact (P = 0.002). A "50% responder" analysis showed no difference in outcome of acute and preventive treatment between patients with and without CA during headache attack. Patients with CH commonly experienced CA during headache attack, but not between headache attacks. CA during headache attack was associated with disease duration, depression, and anxiety.
Files in This Item:
T201903404.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Chu, Min Kyung(주민경) ORCID logo https://orcid.org/0000-0001-6221-1346
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.