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Predictive performance of plasma neutrophil gelatinase-associated lipocalin for neurologic outcomes in out-of-hospital cardiac arrest patients treated with targeted temperature management: A prospective observational study
DC Field | Value | Language |
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dc.contributor.author | 김민정 | - |
dc.contributor.author | 박유석 | - |
dc.contributor.author | 박인철 | - |
dc.contributor.author | 박형천 | - |
dc.contributor.author | 유제성 | - |
dc.contributor.author | 이혜선 | - |
dc.contributor.author | 정성필 | - |
dc.contributor.author | 이지환 | - |
dc.date.accessioned | 2019-10-28T01:41:38Z | - |
dc.date.available | 2019-10-28T01:41:38Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171299 | - |
dc.description.abstract | Few studies have demonstrated the prognostic potential of neutrophil gelatinase-associated lipocalin (NGAL) in post-cardiac arrest patients. This study evaluated the usefulness of plasma NGAL in predicting neurologic outcome and mortality in out-of-hospital cardiac arrest (OHCA) patients treated with targeted temperature management (TTM). A prospective observational study was conducted between October 2013 and April 2016 at a single tertiary hospital. We enrolled 75 patients treated with TTM and collected their demographic data, cardiopulmonary resuscitation-related information, data on plasma NGAL concentration, and prognostic test results. Plasma NGAL was measured at 4 hours after return of spontaneous circulation (ROSC). The primary endpoint was the neurologic outcome at discharge and the secondary outcome was 28-day mortality. Neurologic outcomes were analyzed using a stepwise multivariate logistic regression while 28-day mortality was analyzed using a stepwise Cox regression. The predictive performance of plasma NGAL for neurologic outcome was measured by the area under the receiver operating characteristic curve and the predictability of 28-day mortality was measured using Harrell C-index. We also compared the predictive performance of plasma NGAL to that of other traditional prognostic modalities for outcome variables. Thirty patients (40%) had good neurologic outcomes and 53 (70.7%) survived for more than 28 days. Plasma NGAL in patients with good neurologic outcomes was 122.7 ± 146.7 ng/ml, which was significantly lower than that in the poor neurologic outcome group (307.5 ± 269.6 ng/ml; P < .001). The probability of a poor neurologic outcome was more than 3.3-fold in the NGAL >124.3 ng/ml group (odds ratio, 3.321; 95% confidence interval [CI], 1.265-8.721]). Plasma NGAL in the survived group was significantly lower than that in the non-survived group (172.7 ± 191.6 vs 379.9 ± 297.8 ng/ml; P = .005). Plasma NGAL was significantly correlated with 28-day mortality (hazard ratio 1.003, 95% CI 1.001-1.004; P < .001). The predictive performance of plasma NGAL was not inferior to that of other prognostic modalities except electroencephalography. Plasma NGAL is valuable for predicting the neurologic outcome and 28-day mortality of patients with OHCA at an early stage after ROSC.This study was registered at ClinicalTrials.gov on November 19, 2013 (Identifier: NCT01987466). | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | Medicine | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Area Under Curve | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypothermia, Induced/statistics & numerical data* | - |
dc.subject.MESH | Lipocalin-2/blood* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Out-of-Hospital Cardiac Arrest/blood* | - |
dc.subject.MESH | Out-of-Hospital Cardiac Arrest/mortality | - |
dc.subject.MESH | Out-of-Hospital Cardiac Arrest/therapy | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Prospective Studies | - |
dc.title | Predictive performance of plasma neutrophil gelatinase-associated lipocalin for neurologic outcomes in out-of-hospital cardiac arrest patients treated with targeted temperature management: A prospective observational study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Emergency Medicine (응급의학교실) | - |
dc.contributor.googleauthor | Ji Hwan Lee | - |
dc.contributor.googleauthor | Incheol Park | - |
dc.contributor.googleauthor | Je Sung You | - |
dc.contributor.googleauthor | Min Joung Kim | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Yoo Seok Park | - |
dc.contributor.googleauthor | Hyeong Cheon Park | - |
dc.contributor.googleauthor | Sung Phil Chung | - |
dc.identifier.doi | 10.1097/MD.0000000000016930 | - |
dc.contributor.localId | A00470 | - |
dc.contributor.localId | A01592 | - |
dc.contributor.localId | A01628 | - |
dc.contributor.localId | A01759 | - |
dc.contributor.localId | A02507 | - |
dc.contributor.localId | A03312 | - |
dc.contributor.localId | A03625 | - |
dc.contributor.localId | A05746 | - |
dc.relation.journalcode | J02214 | - |
dc.identifier.eissn | 1536-5964 | - |
dc.identifier.pmid | 31441881 | - |
dc.contributor.alternativeName | Kim, Min Joung | - |
dc.contributor.affiliatedAuthor | 김민정 | - |
dc.contributor.affiliatedAuthor | 박유석 | - |
dc.contributor.affiliatedAuthor | 박인철 | - |
dc.contributor.affiliatedAuthor | 박형천 | - |
dc.contributor.affiliatedAuthor | 유제성 | - |
dc.contributor.affiliatedAuthor | 이혜선 | - |
dc.contributor.affiliatedAuthor | 정성필 | - |
dc.contributor.affiliatedAuthor | 이지환 | - |
dc.citation.volume | 98 | - |
dc.citation.number | 34 | - |
dc.citation.startPage | e16930 | - |
dc.identifier.bibliographicCitation | Medicine, Vol.98(34) : e16930, 2019 | - |
dc.identifier.rimsid | 63934 | - |
dc.type.rims | ART | - |
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