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Recent advances in molecular diagnostics and understanding mechanisms of drug resistance in nontuberculous mycobacterial diseases

Authors
 Hee Jae Huh  ;  Su-Young Kim  ;  Byung Woo Jhun  ;  Sung Jae Shin  ;  Won-Jung Koh 
Citation
 Infection Genetics and Evolution, Vol.72 : 169-182, 2019 
Journal Title
 Infection Genetics and Evolution 
ISSN
 1567-1348 
Issue Date
2019
Keywords
Mycobacterium abscessus ; Mycobacterium avium complex ; Mycobacterium kansasii ; Nontuberculous mycobacteria ; diagnosis ; drug resistance
Abstract
Accumulating evidence suggests that human infections caused by nontuberculous mycobacteria (NTM) are increasing worldwide, indicating that NTM disease is no longer uncommon in many countries. As a result of an increasing emphasis on the importance of differential identification of NTM species, several molecular tools have recently been introduced in clinical and experimental settings. These advances have led to a much better understanding of the diversity of NTM species with regard to clinical aspects and the potential factors responsible for drug resistance that influence the different outcomes of NTM disease. In this paper, we review currently available molecular diagnostics for identification and differentiation of NTM species by summarizing data from recently applied methods, including commercially available assays, and their relevant strengths and weaknesses. We also highlight drug resistance-associated genes in clinically important NTM species. Understanding the basis for different treatment outcomes with different causative species and drug-resistance mechanisms will eventually improve current treatment regimens and facilitate the development of better control measures for NTM diseases.
Full Text
https://www.sciencedirect.com/science/article/pii/S1567134818307846
DOI
10.1016/j.meegid.2018.10.003
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Shin, Sung Jae(신성재) ORCID logo https://orcid.org/0000-0003-0854-4582
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171280
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