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Optimal lexicon of gadoxetic acid-enhanced magnetic resonance imaging for the diagnosis of hepatocellular carcinoma modified from LI-RADS

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dc.contributor.author박미숙-
dc.contributor.author박영년-
dc.contributor.author최진영-
dc.contributor.author한경화-
dc.date.accessioned2019-10-28T01:37:52Z-
dc.date.available2019-10-28T01:37:52Z-
dc.date.issued2019-
dc.identifier.issn2366-004X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171276-
dc.description.abstractPURPOSE: To define the optimal lexicon of major imaging findings on gadoxetic acid-enhanced MRIs to diagnose HCC to improve diagnostic performance of the LI-RADS. METHODS: Two hundred forty-one hepatic lesions (149 HCC, six other malignancies, 86 benign lesions) in 177 treatment-naïve patients at risk of HCC who underwent gadoxetic acid-MRIs from January 2013 to December 2015 were retrospectively reviewed using either histopathological or follow-up imaging findings as a standard reference. Two board-certified radiologists independently evaluated the imaging features and categorized the nodules based on the original and the following modified definitions in LI-RADS: (1) washout appearance in the portal venous phase (PVP) only versus that in the PVP or transitional phase, and (2) enhancing capsule only versus enhancing or non-enhancing capsule. Diagnostic performance and inter-observer agreement of LR-5 were assessed and compared between the algorithms using generalized estimation equation. RESULTS: The sensitivity [79.2% (95% confidence interval 71.9, 85.0)] and accuracy [84.6% (79.5, 88.7)] of LR-5 were significantly higher for modified lexicon compared with original LI-RADS [60.4% (52.3, 67.9) and 73.9% (67.9, 79.0); P < 0.001 in all cases]. There was no significant difference in specificity [93.5% (86.2, 97.0) and 95.7% (89.0, 98.4); P = 0.153]. Subgroups of lesions < or ≥ 2 cm showed similar tendencies. Inter-observer agreement for capsule appearance was fair to moderate, whereas that for other imaging findings was good to excellent. CONCLUSIONS: Compared to original LI-RADS, LI-RADS with modified lexicon showed higher sensitivity for the diagnosis of HCC using gadoxetic acid-MRI, with similar specificity.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer-
dc.relation.isPartOfAbdominal Radiology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleOptimal lexicon of gadoxetic acid-enhanced magnetic resonance imaging for the diagnosis of hepatocellular carcinoma modified from LI-RADS-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorShin Hye Hwang-
dc.contributor.googleauthorSumi Park-
dc.contributor.googleauthorKyunghwa Han-
dc.contributor.googleauthorJin-young Choi-
dc.contributor.googleauthorYoung-Nyun Park-
dc.contributor.googleauthorMi-Suk Park-
dc.identifier.doi10.1007/s00261-019-02077-1-
dc.contributor.localIdA01463-
dc.contributor.localIdA01563-
dc.contributor.localIdA01563-
dc.contributor.localIdA04200-
dc.contributor.localIdA04200-
dc.relation.journalcodeJ03314-
dc.identifier.eissn2366-0058-
dc.identifier.pmid31165907-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs00261-019-02077-1-
dc.subject.keywordDiagnosis-
dc.subject.keywordGadoxetic acid-
dc.subject.keywordHepatocellular carcinoma-
dc.subject.keywordMRI (Magnetic resonance imaging)-
dc.contributor.alternativeNamePark, Mi Sook-
dc.contributor.affiliatedAuthor박미숙-
dc.contributor.affiliatedAuthor박영년-
dc.contributor.affiliatedAuthor박영년-
dc.contributor.affiliatedAuthor최진영-
dc.contributor.affiliatedAuthor최진영-
dc.citation.volume44-
dc.citation.number9-
dc.citation.startPage3078-
dc.citation.endPage3088-
dc.identifier.bibliographicCitationAbdominal Radiology, Vol.44(9) : 3078-3088, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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