28 70

Cited 0 times in

Expression of proteins related to autotaxin-lysophosphatidate signaling in thyroid tumors

Authors
 Eunah Shin  ;  Ja Seung Koo 
Citation
 Journal of Translational Medicine, Vol.17(1) : 288, 2019 
Journal Title
 Journal of Translational Medicine 
Issue Date
2019
Keywords
Autotaxin ; Lysophosphatidate ; Thyroid ; Tumor
Abstract
BACKGROUND: We aimed to investigate the expression of proteins related with autotaxin (ATX)-lysophosphatidate (LPA) signaling and the clinical implications in primary and metastatic thyroid tumors. METHODS: We constructed tissue microarrays with 545 primary thyroid tumors [338 papillary thyroid carcinoma (PTC), 111 follicular carcinoma (FC), 69 medullary carcinoma (MC), 23 poorly differentiated carcinoma (PDC), and four anaplastic carcinoma (AC)]. Immunohistochemical stains for proteins related to ATX-LPA signaling (e.g., ATX, LPA1, LPA2, and LPA3) were performed. RESULTS: The expression of ATX was highest in MC, while the LPA1 expression was higher in PDC and AC, and the expression of LPA2 and LPA3 was highest in PTC (p < 0.001). Additionally, the expression of ATX, LPA1, and LPA2 was higher in conventional-type PTC than in follicular-variant PTC (p < 0.05). PTC with BRAF V600E mutation showed higher expression of ATX, LPA1, LPA2, and LPA3 than PTC without BRAF V600E mutation (p < 0.001). In univariate analysis, ATX positivity (p = 0.005) and LPA1 positivity (p = 0.014) were correlated with shorter overall survival in PTC. CONCLUSION: Proteins related to the ATX-LPA axis showed different levels of expression in primary thyroid tumors according to subtype.
Files in This Item:
T201903180.pdf Download
DOI
10.1186/s12967-019-2028-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koo, Ja Seung(구자승) ORCID logo https://orcid.org/0000-0003-4546-4709
Shin, Eunah(신은아)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171265
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links