Cited 4 times in
Expression of proteins related to autotaxin-lysophosphatidate signaling in thyroid tumors
DC Field | Value | Language |
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dc.contributor.author | 구자승 | - |
dc.contributor.author | 신은아 | - |
dc.date.accessioned | 2019-10-28T01:35:51Z | - |
dc.date.available | 2019-10-28T01:35:51Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171265 | - |
dc.description.abstract | BACKGROUND: We aimed to investigate the expression of proteins related with autotaxin (ATX)-lysophosphatidate (LPA) signaling and the clinical implications in primary and metastatic thyroid tumors. METHODS: We constructed tissue microarrays with 545 primary thyroid tumors [338 papillary thyroid carcinoma (PTC), 111 follicular carcinoma (FC), 69 medullary carcinoma (MC), 23 poorly differentiated carcinoma (PDC), and four anaplastic carcinoma (AC)]. Immunohistochemical stains for proteins related to ATX-LPA signaling (e.g., ATX, LPA1, LPA2, and LPA3) were performed. RESULTS: The expression of ATX was highest in MC, while the LPA1 expression was higher in PDC and AC, and the expression of LPA2 and LPA3 was highest in PTC (p < 0.001). Additionally, the expression of ATX, LPA1, and LPA2 was higher in conventional-type PTC than in follicular-variant PTC (p < 0.05). PTC with BRAF V600E mutation showed higher expression of ATX, LPA1, LPA2, and LPA3 than PTC without BRAF V600E mutation (p < 0.001). In univariate analysis, ATX positivity (p = 0.005) and LPA1 positivity (p = 0.014) were correlated with shorter overall survival in PTC. CONCLUSION: Proteins related to the ATX-LPA axis showed different levels of expression in primary thyroid tumors according to subtype. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | BioMed Central | - |
dc.relation.isPartOf | Journal of Translational Medicine | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Expression of proteins related to autotaxin-lysophosphatidate signaling in thyroid tumors | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Eunah Shin | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.identifier.doi | 10.1186/s12967-019-2028-7 | - |
dc.contributor.localId | A00198 | - |
dc.relation.journalcode | J01915 | - |
dc.identifier.eissn | 1479-5876 | - |
dc.identifier.pmid | 31455351 | - |
dc.subject.keyword | Autotaxin | - |
dc.subject.keyword | Lysophosphatidate | - |
dc.subject.keyword | Thyroid | - |
dc.subject.keyword | Tumor | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.citation.volume | 17 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 288 | - |
dc.identifier.bibliographicCitation | Journal of Translational Medicine, Vol.17(1) : 288, 2019 | - |
dc.identifier.rimsid | 63875 | - |
dc.type.rims | ART | - |
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