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Dyslipidemia and Rate of Under-Target Low-Density Lipoprotein-Cholesterol in Patients with Coronary Artery Disease in Korea

Authors
 Sang-Hak Lee  ;  Woo-Hyuk Song  ;  Myung Ho Jeong  ;  Seung-Ho Hur  ;  Dong Woon Jeon  ;  Wonju Jeung  ;  Anselm K Git  ;  Martin Horack  ;  Ami Vyas  ;  Dominik Lautsch  ;  Baishali Ambegaonkar  ;  Philippe Brudi  ;  Yangsoo Jang 
Citation
 Journal of Lipid and Atherosclerosis, Vol.8(2) : 242-251, 2019 
Journal Title
 Journal of Lipid and Atherosclerosis 
ISSN
 2287-2892 
Issue Date
2019
Keywords
Cholesterol ; Hydroxymethylglutaryl-CoA reductase inhibitors ; Acute coronary syndrome ; Coronary artery disease ; Dyslipidemias
Abstract
Objective: The aim of this study was to evaluate under target rates of low-density lipoproteincholesterol (LDL-C) in Korean patients with stable coronary artery disease (CAD) or an acute coronary syndrome (ACS) in real world practice. Methods: Dyslipidemia International Study II was an international observational study of patients with stable CAD or an ACS. Lipid profiles and use of lipid-lowering therapy (LLT) were documented at enrollment, and for the ACS cohort, 4 months follow-up was recommended. Rates of under target LDL-C as per European guidelines, were evaluated, and multivariate regression was performed to identify predictive factors of patients presenting under the target. Results: A total of 808 patients were enrolled in Korea, 500 with stable CAD and 308 with ACS. Of these, 90.6% and 52.6% were being treated with LLT, respectively. In the stable CAD group, 40.0% were under target LDL-C, while in ACS group, the rate was 23.7%. A higher statin dose was independently associated with under target LDL-C in both groups (OR, 1.03; p=0.046 [stable CAD] and OR, 1.05; p=0.01 [ACS]). The mean statin dosage (atorvastatin equivalent) was 17 mg/day. In the 79 ACS patients who underwent the follow-up examination, the LDL-C under target rate rose to 59.5%. Conclusion: Only a minority of patients with stable CAD or ACS were under their target LDL-C level at enrollment. The statin dose was not sufficient in the majority of patients. These results indicate a considerable LLT gap in Korean patients with established CAD.
Files in This Item:
T201903177.pdf Download
DOI
10.12997/jla.2019.8.2.242
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Sang Hak(이상학) ORCID logo https://orcid.org/0000-0002-4535-3745
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171263
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