Cited 8 times in
Dyslipidemia and Rate of Under-Target Low-Density Lipoprotein-Cholesterol in Patients with Coronary Artery Disease in Korea
DC Field | Value | Language |
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dc.contributor.author | 이상학 | - |
dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2019-10-28T01:35:41Z | - |
dc.date.available | 2019-10-28T01:35:41Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 2287-2892 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171263 | - |
dc.description.abstract | Objective: The aim of this study was to evaluate under target rates of low-density lipoproteincholesterol (LDL-C) in Korean patients with stable coronary artery disease (CAD) or an acute coronary syndrome (ACS) in real world practice. Methods: Dyslipidemia International Study II was an international observational study of patients with stable CAD or an ACS. Lipid profiles and use of lipid-lowering therapy (LLT) were documented at enrollment, and for the ACS cohort, 4 months follow-up was recommended. Rates of under target LDL-C as per European guidelines, were evaluated, and multivariate regression was performed to identify predictive factors of patients presenting under the target. Results: A total of 808 patients were enrolled in Korea, 500 with stable CAD and 308 with ACS. Of these, 90.6% and 52.6% were being treated with LLT, respectively. In the stable CAD group, 40.0% were under target LDL-C, while in ACS group, the rate was 23.7%. A higher statin dose was independently associated with under target LDL-C in both groups (OR, 1.03; p=0.046 [stable CAD] and OR, 1.05; p=0.01 [ACS]). The mean statin dosage (atorvastatin equivalent) was 17 mg/day. In the 79 ACS patients who underwent the follow-up examination, the LDL-C under target rate rose to 59.5%. Conclusion: Only a minority of patients with stable CAD or ACS were under their target LDL-C level at enrollment. The statin dose was not sufficient in the majority of patients. These results indicate a considerable LLT gap in Korean patients with established CAD. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 한국지질동맥경화학회 | - |
dc.relation.isPartOf | Journal of Lipid and Atherosclerosis | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Dyslipidemia and Rate of Under-Target Low-Density Lipoprotein-Cholesterol in Patients with Coronary Artery Disease in Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Sang-Hak Lee | - |
dc.contributor.googleauthor | Woo-Hyuk Song | - |
dc.contributor.googleauthor | Myung Ho Jeong | - |
dc.contributor.googleauthor | Seung-Ho Hur | - |
dc.contributor.googleauthor | Dong Woon Jeon | - |
dc.contributor.googleauthor | Wonju Jeung | - |
dc.contributor.googleauthor | Anselm K Git | - |
dc.contributor.googleauthor | Martin Horack | - |
dc.contributor.googleauthor | Ami Vyas | - |
dc.contributor.googleauthor | Dominik Lautsch | - |
dc.contributor.googleauthor | Baishali Ambegaonkar | - |
dc.contributor.googleauthor | Philippe Brudi | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.identifier.doi | 10.12997/jla.2019.8.2.242 | - |
dc.contributor.localId | A02833 | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J01562 | - |
dc.identifier.eissn | 2288-2561 | - |
dc.subject.keyword | Cholesterol | - |
dc.subject.keyword | Hydroxymethylglutaryl-CoA reductase inhibitors | - |
dc.subject.keyword | Acute coronary syndrome | - |
dc.subject.keyword | Coronary artery disease | - |
dc.subject.keyword | Dyslipidemias | - |
dc.contributor.alternativeName | Lee, Snag Hak | - |
dc.contributor.affiliatedAuthor | 이상학 | - |
dc.contributor.affiliatedAuthor | 장양수 | - |
dc.citation.volume | 8 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 242 | - |
dc.citation.endPage | 251 | - |
dc.identifier.bibliographicCitation | Journal of Lipid and Atherosclerosis, Vol.8(2) : 242-251, 2019 | - |
dc.identifier.rimsid | 64489 | - |
dc.type.rims | ART | - |
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