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Neural Dynamics of Olfactory Perception: Low- and High-Frequency Modulations of Local Field Potential Spectra in Mice Revealed by an Oddball Stimulus

Authors
 Jeungeun Kum  ;  Jin Won Kim  ;  Oliver Braubach  ;  Jong-Gyun Ha  ;  Hyung-Ju Cho  ;  Chang-Hoon Kim  ;  Hio-Been Han  ;  Jee Hyun Choi  ;  Joo-Heon Yoon 
Citation
 Frontiers in Neuroscience, Vol.13 : 478, 2019 
Journal Title
 Frontiers in Neuroscience 
ISSN
 1662-4548 
Issue Date
2019
Keywords
anterior cingulate cortex ; anterior olfactory ; attention ; local field potential ; neural oscillations ; oddball paradigm ; olfaction ; primary olfactory cortex
Abstract
Recent brain connectome studies have evidenced distinct and overlapping brain regions involved in processing olfactory perception. However, neural correlates of hypo- or anosmia in olfactory disorder patients are poorly known. Furthermore, the bottom-up and top-down processing of olfactory perception have not been well-documented, resulting in difficulty in locating the disease foci of olfactory disorder patients. The primary aim of this study is to characterize the bottom-up process of the neural dynamics across peripheral and central brain regions in anesthetized mice. We particularly focused on the neural oscillations of local field potential (LFP) in olfactory epithelium (OE), olfactory blub (OB), prefrontal cortex (PFC), and hippocampus (HC) during an olfactory oddball paradigm in urethane anesthetized mice. Odorant presentations evoked neural oscillations across slow and fast frequency bands including delta (1-4 Hz), theta (6-10 Hz), beta (15-30 Hz), low gamma (30-50 Hz), and high gamma (70-100 Hz) in both peripheral and central nervous systems, and the increases were more prominent in the infrequently presented odorant. During 5 s odorant exposures, the oscillatory responses in power were persistent in OE, OB, and PFC, whereas neural oscillations of HC increased only for short time at stimulus onset. These oscillatory responses in power were insignificant in both peripheral and central regions of the ZnSO4-treated anosmia model. These results suggest that olfactory stimulation induce LFP oscillations both in the peripheral and central nervous systems and suggest the possibility of linkage of LFP oscillations in the brain to the oscillations in the peripheral olfactory system.
Files in This Item:
T201903042.pdf Download
DOI
10.3389/fnins.2019.00478
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin Won(김진원)
Kim, Chang Hoon(김창훈) ORCID logo https://orcid.org/0000-0003-1238-6396
Yoon, Joo Heon(윤주헌)
Cho, Hyung Ju(조형주) ORCID logo https://orcid.org/0000-0002-2851-3225
Ha, Jong Gyun(하종균) ORCID logo https://orcid.org/0000-0002-2712-1297
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171178
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