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Intrinsic expression of viperin regulates thermogenesis in adipose tissues

Authors
 John Eom  ;  Jeong Jin Kim  ;  Seul Gi Yoon  ;  Haengdueng Jeong  ;  Soojin Son  ;  Jae Bong Lee  ;  Jihye Yoo  ;  Hyun Ju Seo  ;  Yejin Cho  ;  Ku Sul Kim  ;  Kyung Mi Choi  ;  Il Yong Kim  ;  Hui-Young Lee  ;  Ki Taek Nam  ;  Peter Cresswell  ;  Je Kyung Seong  ;  Jun-Young Seo 
Citation
 Proceedings of the National Academy of Sciences of the United States of America, Vol.116(35) : 17419-17428, 2019 
Journal Title
 Proceedings of the National Academy of Sciences of the United States of America 
ISSN
 0027-8424 
Issue Date
2019
Keywords
fatty acid β-oxidation ; innate immunity ; metabolism ; thermogenesis ; viperin
Abstract
Viperin is an interferon (IFN)-inducible multifunctional protein. Recent evidence from high-throughput analyses indicates that most IFN-inducible proteins, including viperin, are intrinsically expressed in specific tissues; however, the respective intrinsic functions are unknown. Here we show that the intrinsic expression of viperin regulates adipose tissue thermogenesis, which is known to counter metabolic disease and contribute to the febrile response to pathogen invasion. Viperin knockout mice exhibit increased heat production, resulting in a reduction of fat mass, improvement of high-fat diet (HFD)-induced glucose tolerance, and enhancement of cold tolerance. These thermogenic phenotypes are attributed to an adipocyte-autonomous mechanism that regulates fatty acid β-oxidation. Under an HFD, viperin expression is increased, and its function is enhanced. Our findings reveal the intrinsic function of viperin as a novel mechanism regulating thermogenesis in adipose tissues, suggesting that viperin represents a molecular target for thermoregulation in clinical contexts.
Full Text
https://www.pnas.org/content/116/35/17419.long
DOI
10.1073/pnas.1904480116
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Nam, Ki Taek(남기택)
Seo, Jun Young(서준영) ORCID logo https://orcid.org/0000-0003-4004-2013
Choi, Kyung Mi(최경미)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171152
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