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Intrinsic expression of viperin regulates thermogenesis in adipose tissues

DC FieldValueLanguage
dc.contributor.author남기택-
dc.contributor.author서준영-
dc.contributor.author최경미-
dc.date.accessioned2019-09-20T07:59:13Z-
dc.date.available2019-09-20T07:59:13Z-
dc.date.issued2019-
dc.identifier.issn0027-8424-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171152-
dc.description.abstractViperin is an interferon (IFN)-inducible multifunctional protein. Recent evidence from high-throughput analyses indicates that most IFN-inducible proteins, including viperin, are intrinsically expressed in specific tissues; however, the respective intrinsic functions are unknown. Here we show that the intrinsic expression of viperin regulates adipose tissue thermogenesis, which is known to counter metabolic disease and contribute to the febrile response to pathogen invasion. Viperin knockout mice exhibit increased heat production, resulting in a reduction of fat mass, improvement of high-fat diet (HFD)-induced glucose tolerance, and enhancement of cold tolerance. These thermogenic phenotypes are attributed to an adipocyte-autonomous mechanism that regulates fatty acid β-oxidation. Under an HFD, viperin expression is increased, and its function is enhanced. Our findings reveal the intrinsic function of viperin as a novel mechanism regulating thermogenesis in adipose tissues, suggesting that viperin represents a molecular target for thermoregulation in clinical contexts.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherNational Academy of Sciences-
dc.relation.isPartOfProceedings of the National Academy of Sciences of the United States of America-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleIntrinsic expression of viperin regulates thermogenesis in adipose tissues-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentBioMedical Science Institute (의생명과학부)-
dc.contributor.googleauthorJohn Eom-
dc.contributor.googleauthorJeong Jin Kim-
dc.contributor.googleauthorSeul Gi Yoon-
dc.contributor.googleauthorHaengdueng Jeong-
dc.contributor.googleauthorSoojin Son-
dc.contributor.googleauthorJae Bong Lee-
dc.contributor.googleauthorJihye Yoo-
dc.contributor.googleauthorHyun Ju Seo-
dc.contributor.googleauthorYejin Cho-
dc.contributor.googleauthorKu Sul Kim-
dc.contributor.googleauthorKyung Mi Choi-
dc.contributor.googleauthorIl Yong Kim-
dc.contributor.googleauthorHui-Young Lee-
dc.contributor.googleauthorKi Taek Nam-
dc.contributor.googleauthorPeter Cresswell-
dc.contributor.googleauthorJe Kyung Seong-
dc.contributor.googleauthorJun-Young Seo-
dc.identifier.doi10.1073/pnas.1904480116-
dc.contributor.localIdA01243-
dc.contributor.localIdA01911-
dc.contributor.localIdA01911-
dc.contributor.localIdA05051-
dc.contributor.localIdA05051-
dc.relation.journalcodeJ02550-
dc.identifier.eissn1091-6490-
dc.identifier.pmid31341090-
dc.identifier.urlhttps://www.pnas.org/content/116/35/17419.long-
dc.subject.keywordfatty acid β-oxidation-
dc.subject.keywordinnate immunity-
dc.subject.keywordmetabolism-
dc.subject.keywordthermogenesis-
dc.subject.keywordviperin-
dc.contributor.alternativeNameNam, Ki Taek-
dc.contributor.affiliatedAuthor남기택-
dc.contributor.affiliatedAuthor서준영-
dc.contributor.affiliatedAuthor서준영-
dc.contributor.affiliatedAuthor최경미-
dc.contributor.affiliatedAuthor최경미-
dc.citation.volume116-
dc.citation.number35-
dc.citation.startPage17419-
dc.citation.endPage17428-
dc.identifier.bibliographicCitationProceedings of the National Academy of Sciences of the United States of America, Vol.116(35) : 17419-17428, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

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