Cited 5 times in
PEGylated Magnetic Nano-Assemblies as Contrast Agents for Effective T2-Weighted MR Imaging
DC Field | Value | Language |
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dc.contributor.author | 손혜영 | - |
dc.contributor.author | 허용민 | - |
dc.date.accessioned | 2019-09-20T07:50:13Z | - |
dc.date.available | 2019-09-20T07:50:13Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171077 | - |
dc.description.abstract | We designed a high-sensitivity magnetic resonance imaging contrast agent that could be used to diagnose diseases. First, magnetic nanocrystals were synthesized by a thermal decomposition method on an organic solvent to obtain a high magnetism and methoxy poly(ethylene glycol)-poly(lactic acid) as an amphiphilic polymer using the ring-opening polymerization method to stably disperse the magnetic nanocrystals in an aqueous phase. Subsequently, the magnetic nanoclusters simultaneously self-assembled with methoxy poly(ethylene glycol)-poly(lactic acid) using the nano-emulsion method to form magnetic nanoclusters. Because their shape was similar to a raspberry, they were named PEGylated magnetic nano-assemblies. The PEGylated magnetic nano-assemblies were dispersed stably in the aqueous phase with a uniform size of approximately 65⁻70 nm for an extended period (0 days: 68.8 ± 5.1 nm, 33 days: 69.2 ± 2.0 nm, and 44 days: 63.2 ± 5.6). They exhibited both enough of a magnetic resonance (MR) contrast effect and biocompatibility. In an in vivo study, the PEGylated magnetic nano-assemblies provided a high contrast effect for magnetic resonance images for a long time after one treatment, thereby improving the diagnostic visibility of the disease site. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | Nanomaterials | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | PEGylated Magnetic Nano-Assemblies as Contrast Agents for Effective T2-Weighted MR Imaging | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | BioMedical Science Institute (의생명과학부) | - |
dc.contributor.googleauthor | Byunghoon Kang | - |
dc.contributor.googleauthor | Jaewoo Lim | - |
dc.contributor.googleauthor | Hye-young Son | - |
dc.contributor.googleauthor | Yuna Choi | - |
dc.contributor.googleauthor | Taejoon Kang | - |
dc.contributor.googleauthor | Juyeon Jung | - |
dc.contributor.googleauthor | Yong-Min Huh | - |
dc.contributor.googleauthor | Seungjoo Haam | - |
dc.contributor.googleauthor | Eun-Kyung Lim | - |
dc.identifier.doi | 10.3390/nano9030410 | - |
dc.contributor.localId | A04589 | - |
dc.contributor.localId | A04359 | - |
dc.relation.journalcode | J03655 | - |
dc.identifier.eissn | 2079-4991 | - |
dc.identifier.pmid | 30862030 | - |
dc.subject.keyword | Magnetic resonance image | - |
dc.subject.keyword | PEGylated | - |
dc.subject.keyword | Poly(ethylene glycol)-poly(lactic acid) | - |
dc.subject.keyword | contrast agent | - |
dc.contributor.alternativeName | Son, Hye Yeong | - |
dc.contributor.affiliatedAuthor | 손혜영 | - |
dc.contributor.affiliatedAuthor | 허용민 | - |
dc.citation.volume | 9 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | E410 | - |
dc.identifier.bibliographicCitation | Nanomaterials, Vol.9(3) : E410, 2019 | - |
dc.identifier.rimsid | 64262 | - |
dc.type.rims | ART | - |
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