38 49

Cited 0 times in

PKM2 enhances cancer invasion via ETS-1-dependent induction of matrix metalloproteinase in oral squamous cell carcinoma cells

DC FieldValueLanguage
dc.contributor.author김주영-
dc.contributor.author김진-
dc.contributor.author박영진-
dc.contributor.author장향란-
dc.contributor.author정원윤-
dc.date.accessioned2019-09-20T07:41:07Z-
dc.date.available2019-09-20T07:41:07Z-
dc.date.issued2019-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171011-
dc.description.abstractOBJECTIVES: This study aimed at investigating the molecular mechanism underlying PKM2-mediated cancer invasion. MATERIALS & METHODS: To optimize the investigation of PKM2-specific effects, we used two immortalized oral cell lines. The two cell lines drastically differed in PKM2 expression level, particularly in the level of nuclear PKM2, and subsequently in glucose metabolism and tumorigenicity. RESULTS: Knockdown of PKM2 reduced not only the glucose metabolism but also the invasive activity by curtailing the expressions of matrix metalloproteinases (MMP): PKM2 could modulate MMP-9 expression by regulating ETS-1 inside the nucleus. These results were further confirmed in an oral squamous cell carcinoma (OSCC) cell line. In correspondence with in vitro findings, clinicopathological data from OSCC patients indicated strong association between PKM2 expression and poor survival rate. Additionally, upon analysis of public database, significant positive correlation was found between PKM2 and ETS-1 in OSCC. CONCLUSION: Collectively, this study unveiled the molecular mechanism underlying PKM2-mediated cancer invasion, thereby providing novel targets for therapeutics development against invasive OSCC.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLoS One-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titlePKM2 enhances cancer invasion via ETS-1-dependent induction of matrix metalloproteinase in oral squamous cell carcinoma cells-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Pathology (구강병리학교실)-
dc.contributor.googleauthorYoung-Jin Park-
dc.contributor.googleauthorJue Young Kim-
dc.contributor.googleauthorDoo Young Lee-
dc.contributor.googleauthorXianglan Zhang-
dc.contributor.googleauthorShadavlonjid Bazarsad-
dc.contributor.googleauthorWon-Yoon Chung-
dc.contributor.googleauthorJin Kim-
dc.identifier.doi10.1371/journal.pone.0216661-
dc.contributor.localIdA00936-
dc.contributor.localIdA01009-
dc.contributor.localIdA01009-
dc.contributor.localIdA01571-1-
dc.contributor.localIdA01571-1-
dc.contributor.localIdA03489-
dc.contributor.localIdA03489-
dc.contributor.localIdA03676-
dc.contributor.localIdA03676-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid31071178-
dc.contributor.alternativeNameKim, Ju Young-
dc.contributor.affiliatedAuthor김주영-
dc.contributor.affiliatedAuthor김진-
dc.contributor.affiliatedAuthor김진-
dc.contributor.affiliatedAuthor박영진-
dc.contributor.affiliatedAuthor박영진-
dc.contributor.affiliatedAuthor장향란-
dc.contributor.affiliatedAuthor장향란-
dc.contributor.affiliatedAuthor정원윤-
dc.contributor.affiliatedAuthor정원윤-
dc.citation.volume14-
dc.citation.number5-
dc.citation.startPagee0216661-
dc.identifier.bibliographicCitationPLoS One, Vol.14(5) : e0216661, 2019-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.