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Absence of neutralizing activity in serum 1 year after successful treatment with antivirals and recovery from MERS in South Korea

Authors
 Jun Yong Choi  ;  Jin Ok Oh  ;  Jin Young Ahn  ;  Heun Choi  ;  Jung Ho Kim  ;  Hye Seong  ;  Su Jin Jeong  ;  Nam Su Ku  ;  Joon-Sup Yeom  ;  Jae-Phil Choi 
Citation
 Clinical Experimental Vaccine Research, Vol.8(1) : 86-88, 2019 
Journal Title
 Clinical Experimental Vaccine Research 
ISSN
 2287-3651 
Issue Date
2019
Keywords
Middle East respiratory syndrome coronavirus ; Neutralizing antibodies ; Serum
Abstract
We evaluated the neutralizing activity in serum from three patients >1 year after recovery from Middle East respiratory syndrome (MERS) associated with mild pneumonia treated with antivirals during the MERS outbreak in South Korea at 2015. The neutralizing activity in serum was measured by pseudovirus inhibition assays. Three-fold diluted serum of subjects showed only 9.7%, 10.3%, and 2.2% reductions in relative light units. So, significant neutralizing activity was not demonstrated in any sera of three patients with mild pneumonia >1 year after being successfully treated with antiviral agents and recovering from MERS coronavirus infection.
Files in This Item:
T201902560.pdf Download
DOI
10.7774/cevr.2019.8.1.86
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ku, Nam Su(구남수) ORCID logo https://orcid.org/0000-0002-9717-4327
Kim, Jung Ho(김정호) ORCID logo https://orcid.org/0000-0002-5033-3482
Seong, Hye(성혜) ORCID logo https://orcid.org/0000-0002-5633-7214
Ahn, Jin Young(안진영) ORCID logo https://orcid.org/0000-0002-3740-2826
Yeom, Joon Sup(염준섭) ORCID logo https://orcid.org/0000-0001-8940-7170
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
Choi, Heun(최흔) ORCID logo https://orcid.org/0000-0002-9622-9381
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170991
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