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Implication of total tumor size on the prognosis of patients with clinical stage IA lung adenocarcinomas appearing as part-solid nodules: Does only the solid portion size matter?
DC Field | Value | Language |
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dc.contributor.author | 서영주 | - |
dc.date.accessioned | 2019-09-20T07:37:12Z | - |
dc.date.available | 2019-09-20T07:37:12Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0938-7994 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/170978 | - |
dc.description.abstract | OBJECTIVES: The aim was to investigate the effect of clinico-radiologic variables, including total tumor (Ttotal) size and clinical T category, on the prognosis of patients with stage IA (T1N0M0) lung adenocarcinomas appearing as part-solid nodules (PSNs). METHODS: This institutional review board-approved retrospective study included 506 patients (male:female = 200:306; median age, 62 years) with PSNs of the adenocarcinoma spectrum in clinical stage IA who underwent standard lobectomy at a single tertiary medical center. Prognostic stratification of the patients in terms of disease-free survival was analyzed with variables including age, sex, Ttotal size, solid portion size, clinical T category, and tumor location using univariate and subsequent multivariate Cox regression analysis. Subgroup analysis was performed to reveal the effect of the Ttotal size at each clinical T category. RESULTS: Multivariate Cox regression analysis demonstrated that Ttotal size*cT1b [interaction term; hazard ratio (HR) = 1.091; 95% confidence interval (CI): 1.015, 1.173; p = 0.019] and cT1c (HR = 68.436; 95% CI: 2.797, 1674.415; p = 0.010) were independent risk factors for the tumor recurrence. When patients with cT1b were dichotomized based on a Ttotal size cutoff of 3.0 cm, PSNs with Ttotal > 3.0 cm showed a significantly worse outcome (HR = 3.796; 95% CI: 1.006, 14.317; p = 0.049). No significant difference was observed in the probability of recurrence between cT1b with Ttotal > 3.0 cm and cT1c (p = 0.915). CONCLUSIONS: Ttotal size is a significant prognostic factor in adenocarcinoma patients in cT1b without lymph node or distant metastasis. PSNs in cT1b with Ttotal > 3.0 cm have a comparable risk of lung cancer recurrence to those in cT1c. KEY POINTS: • Current T descriptor was a powerful prognostic factor in stage IA adenocarcinomas appearing as part-solid nodules. • Total tumor size further stratified risk of recurrence of adenocarcinomas in cT1b. • Upstaging of tumors in cT1b with total tumor size > 3.0 cm may be more appropriate. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer International | - |
dc.relation.isPartOf | European Radiology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adenocarcinoma of Lung/diagnostic imaging | - |
dc.subject.MESH | Adenocarcinoma of Lung/pathology* | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lung Neoplasms/diagnostic imaging | - |
dc.subject.MESH | Lung Neoplasms/pathology* | - |
dc.subject.MESH | Lymph Nodes/pathology | - |
dc.subject.MESH | Lymphatic Metastasis | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Metastasis | - |
dc.subject.MESH | Neoplasm Recurrence, Local | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Tomography, X-Ray Computed | - |
dc.subject.MESH | Tumor Burden* | - |
dc.title | Implication of total tumor size on the prognosis of patients with clinical stage IA lung adenocarcinomas appearing as part-solid nodules: Does only the solid portion size matter? | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Hyungjin Kim | - |
dc.contributor.googleauthor | Jin Mo Goo | - |
dc.contributor.googleauthor | Young Joo Suh | - |
dc.contributor.googleauthor | Chang Min Park | - |
dc.contributor.googleauthor | Young Tae Kim | - |
dc.identifier.doi | 10.1007/s00330-018-5685-7 | - |
dc.contributor.localId | A01892 | - |
dc.relation.journalcode | J00851 | - |
dc.identifier.eissn | 1432-1084 | - |
dc.identifier.pmid | 30132107 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00330-018-5685-7 | - |
dc.subject.keyword | Adenocarcinoma | - |
dc.subject.keyword | Disease-free survival | - |
dc.subject.keyword | Lung neoplasms | - |
dc.subject.keyword | Neoplasm staging | - |
dc.subject.keyword | Prognosis | - |
dc.contributor.alternativeName | Suh, Young Joo | - |
dc.contributor.affiliatedAuthor | 서영주 | - |
dc.citation.volume | 29 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1586 | - |
dc.citation.endPage | 1594 | - |
dc.identifier.bibliographicCitation | European Radiology, Vol.29(3) : 1586-1594, 2019 | - |
dc.identifier.rimsid | 64293 | - |
dc.type.rims | ART | - |
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