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Implication of total tumor size on the prognosis of patients with clinical stage IA lung adenocarcinomas appearing as part-solid nodules: Does only the solid portion size matter?

DC FieldValueLanguage
dc.contributor.author서영주-
dc.date.accessioned2019-09-20T07:37:12Z-
dc.date.available2019-09-20T07:37:12Z-
dc.date.issued2019-
dc.identifier.issn0938-7994-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/170978-
dc.description.abstractOBJECTIVES: The aim was to investigate the effect of clinico-radiologic variables, including total tumor (Ttotal) size and clinical T category, on the prognosis of patients with stage IA (T1N0M0) lung adenocarcinomas appearing as part-solid nodules (PSNs). METHODS: This institutional review board-approved retrospective study included 506 patients (male:female = 200:306; median age, 62 years) with PSNs of the adenocarcinoma spectrum in clinical stage IA who underwent standard lobectomy at a single tertiary medical center. Prognostic stratification of the patients in terms of disease-free survival was analyzed with variables including age, sex, Ttotal size, solid portion size, clinical T category, and tumor location using univariate and subsequent multivariate Cox regression analysis. Subgroup analysis was performed to reveal the effect of the Ttotal size at each clinical T category. RESULTS: Multivariate Cox regression analysis demonstrated that Ttotal size*cT1b [interaction term; hazard ratio (HR) = 1.091; 95% confidence interval (CI): 1.015, 1.173; p = 0.019] and cT1c (HR = 68.436; 95% CI: 2.797, 1674.415; p = 0.010) were independent risk factors for the tumor recurrence. When patients with cT1b were dichotomized based on a Ttotal size cutoff of 3.0 cm, PSNs with Ttotal > 3.0 cm showed a significantly worse outcome (HR = 3.796; 95% CI: 1.006, 14.317; p = 0.049). No significant difference was observed in the probability of recurrence between cT1b with Ttotal > 3.0 cm and cT1c (p = 0.915). CONCLUSIONS: Ttotal size is a significant prognostic factor in adenocarcinoma patients in cT1b without lymph node or distant metastasis. PSNs in cT1b with Ttotal > 3.0 cm have a comparable risk of lung cancer recurrence to those in cT1c. KEY POINTS: • Current T descriptor was a powerful prognostic factor in stage IA adenocarcinomas appearing as part-solid nodules. • Total tumor size further stratified risk of recurrence of adenocarcinomas in cT1b. • Upstaging of tumors in cT1b with total tumor size > 3.0 cm may be more appropriate.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer International-
dc.relation.isPartOfEuropean Radiology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdenocarcinoma of Lung/diagnostic imaging-
dc.subject.MESHAdenocarcinoma of Lung/pathology*-
dc.subject.MESHAged-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLung Neoplasms/diagnostic imaging-
dc.subject.MESHLung Neoplasms/pathology*-
dc.subject.MESHLymph Nodes/pathology-
dc.subject.MESHLymphatic Metastasis-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Metastasis-
dc.subject.MESHNeoplasm Recurrence, Local-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPrognosis-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHTomography, X-Ray Computed-
dc.subject.MESHTumor Burden*-
dc.titleImplication of total tumor size on the prognosis of patients with clinical stage IA lung adenocarcinomas appearing as part-solid nodules: Does only the solid portion size matter?-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorHyungjin Kim-
dc.contributor.googleauthorJin Mo Goo-
dc.contributor.googleauthorYoung Joo Suh-
dc.contributor.googleauthorChang Min Park-
dc.contributor.googleauthorYoung Tae Kim-
dc.identifier.doi10.1007/s00330-018-5685-7-
dc.contributor.localIdA01892-
dc.relation.journalcodeJ00851-
dc.identifier.eissn1432-1084-
dc.identifier.pmid30132107-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs00330-018-5685-7-
dc.subject.keywordAdenocarcinoma-
dc.subject.keywordDisease-free survival-
dc.subject.keywordLung neoplasms-
dc.subject.keywordNeoplasm staging-
dc.subject.keywordPrognosis-
dc.contributor.alternativeNameSuh, Young Joo-
dc.contributor.affiliatedAuthor서영주-
dc.citation.volume29-
dc.citation.number3-
dc.citation.startPage1586-
dc.citation.endPage1594-
dc.identifier.bibliographicCitationEuropean Radiology, Vol.29(3) : 1586-1594, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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