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Morningness–Eveningness Questionnaire-Based Chronotype Is Correlated with Atherogenic Index of Plasma

 Yu-Jin Kwon  ;  Ji-Won Lee 
 Chronobiology in Medicine, Vol.1(2) : 74-80, 2019 
Journal Title
Chronobiology in Medicine
Issue Date
Circadian rhythm ; Jetlag ; Sleep
Objective: Our study investigated the correlations of individual chronotype, social jetlag (SJL), and sleep duration with levels of atherogenic
lipids. Methods: This cross-sectional study included 1,984 participants who visited the health check-up centers of two tertiary medical institutions
from July 2016 to December 2016. Chronotype was assessed by the Morningness−Eveningness Questionnaire (MEQ), and sleep duration
and SJL were assessed by a self-reported questionnaire. Simple and partial Pearson’s correlation analyses were used to investigate the relationship
between sleep parameters and lipid profiles. Multiple stepwise and enter method regression analyses were used to find independent
relationships between MEQ score and atherogenic index of plasma (AIP). Results: Participants’ MEQ scores were significantly correlated with
triglyceride levels (r=-0.088, p<0.01), total cholesterol/high-density lipoprotein (TC/HDL; r=-0.059, p<0.05), and AIP (r=-0.089, p<0.01).
Their SJL scores were positively related with TC (r=0.055, p<0.05), while sleep duration was negatively related with HDL-cholesterol (r=-0.053,
p<0.01). Partial Pearson’s correlation analysis showed that MEQ score was more strongly associated with AIP (r=-0.089) than with SJL and
sleep duration (p=0.011 and p=0.031), respectively. A significant association between MEQ score and AIP was found by multiple linear regression
analyses after adjusting for age, sex, body mass index, mean arterial pressure, glucose level, white blood cell count, smoking status, physical
activity, alcohol consumption, and dyslipidemia medication (β=-0.002, p=0.009). Conclusion: Late chronotype is independently and negatively
associated with AIP after adjusting for possible confounders, suggesting these individuals are at increased risk for cardiovascular
disease and may benefit from chronotherapy to limit its incidence in this population.
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1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Yu-Jin(권유진) ORCID logo https://orcid.org/0000-0002-9021-3856
Lee, Ji Won(이지원) ORCID logo https://orcid.org/0000-0002-2666-4249
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